The effect of exemestane, anastrozole, and tamoxifen on lipid profiles in Japanese postmenopausal early breast cancer patients: final results of National Surgical Adjuvant Study BC 04, the TEAM Japan sub-study
The effect of exemestane, anastrozole, and tamoxifen on lipid profiles in Japanese postmenopausal early breast cancer patients: final results of National Surgical Adjuvant Study BC 04, the TEAM Japan sub-study
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DOI：
10.1093/annonc/mdq707
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发表时间：
2011-08-01
影响因子：
50.5
通讯作者：
Ohashi, Y.
中科院分区：
文献类型：
--
作者：
Hozumi, Y.;Suemasu, K.;Ohashi, Y.
背景资料：在这个他莫昔芬依西美坦辅助多国日本子研究中，我们评估了血脂的变化在绝经后妇女的时间过程中的敏感性早期乳腺癌治疗与依西美坦，阿那曲唑，或他莫昔芬术后辅助therapy.Patients和方法：共154例乳腺癌患者被分配到接受依西美坦，阿那曲唑，或他莫昔芬在这个随机开放标签研究。结果：三苯氧胺治疗3个月后，患者TC、LDL-C迅速下降，TC、LDL-C均明显低于治疗前（P < 0. 05），LDL-C、HDL-C均明显低于治疗前（P < 0. 05）。与阿那曲唑和阿司美坦组相比，他莫昔芬组在所有评估时间点的TC和LDL-C均显著降低（P < 0.05）。他莫昔芬组TG升高，在所有评估时间点均显著高于依西美坦组（P < 0.05）。HDL-C略有下降，阿司美坦组与阿那曲唑组相比，3个月和1年时HDL-C显著降低（P分别为0.0179和0.0013）。结论：日本绝经后妇女接受他莫昔芬治疗后血脂谱的变化相对有利，而阿司美坦和阿那曲唑对血脂无临床显著影响。
Background: In this Tamoxifen Exemestane Adjuvant Multinational Japan sub-study, we evaluated the time course of changes in serum lipids in postmenopausal women with hormone-sensitive early breast cancer treated with exemestane, anastrozole, or tamoxifen for postoperative adjuvant therapy.Patients and methods: A total of 154 breast cancer patients were assigned to receive exemestane, anastrozole, or tamoxifen in this randomized open-label study. Serum lipid parameters including triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) were measured during 1 year of treatment.Results: TC and LDL-C rapidly decreased in patients treated with tamoxifen at 3 months. Compared with anastrozole and exemestane patients, TC and LDL-C were significantly lower at all assessment time points in tamoxifen patients (P < 0.05). TG increased in tamoxifen patients; it was significantly higher compared with exemestane patients at all assessment time points (P < 0.05). HDL-C slightly decreased in exemestane patients; it was significantly lower compared with anastrozole patients at 3 months and 1 year (P = 0.0179 and 0.0013, respectively).Conclusion: Changes of lipid profiles in Japanese postmenopausal women treated with tamoxifen were relatively favorable, while exemestane and anastrozole had no clinically significant effect on the serum lipids.