Role of corin in trophoblast invasion and uterine spiral artery remodelling in pregnancy.
Role of corin in trophoblast invasion and uterine spiral artery remodelling in pregnancy.
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Corin在妊娠期滋养细胞侵袭和子宫螺旋动脉重塑中的作用
DOI：
10.1038/nature10897
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发表时间：
2012-03-21
期刊：
影响因子：
64.8
通讯作者：
Wu, Qingyu
中科院分区：
文献类型：
--
作者：
Cui, Yujie;Wang, Wei;Dong, Ningzheng;Lou, Jinglei;Srinivasan, Dinesh Kumar;Cheng, Weiwei;Huang, Xiaoyi;Liu, Meng;Fang, Chaodong;Peng, Jianhao;Chen, Shenghan;Wu, Shannon;Liu, Zhenzhen;Dong, Liang;Zhou, Yiqing;Wu, Qingyu
In pregnancy, trophoblast invasion and uterine spiral artery remodelling are important for lowering maternal vascular resistance and increasing uteroplacental blood flow. Impaired spiral artery remodelling has been implicated in pre-eclampsia, a major complication of pregnancy, for a long time but the underlying mechanisms remain unclear,. Corin (also known as atrial natriuretic peptide-converting enzyme) is a cardiac protease that activates atrial natriuretic peptide (ANP), a cardiac hormone that is important in regulating blood pressure. Unexpectedly, corin expression was detected in the pregnant uterus. Here we identify a new function of corin and ANP in promoting trophoblast invasion and spiral artery remodelling. We show that pregnant corin- or ANP-deficient mice developed high blood pressure and proteinuria, characteristics of pre-eclampsia. In these mice, trophoblast invasion and uterine spiral artery remodelling were markedly impaired. Consistent with this, the ANP potently stimulated human trophoblasts in invading Matrigels. In patients with pre-eclampsia, uterineCorinmessenger RNA and protein levels were significantly lower than that in normal pregnancies. Moreover, we have identifiedCoringene mutations in pre-eclamptic patients, which decreased corin activity in processing pro-ANP. These results indicate that corin and ANP are essential for physiological changes at the maternal–fetal interface, suggesting that defects in corin and ANP function may contribute to pre-eclampsia.
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DOI：
10.1073/pnas.0407234102
发表时间：
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影响因子：
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DOI：
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