Peptide-enhanced cellular internalization of proteins in neuroscience
Peptide-enhanced cellular internalization of proteins in neuroscience
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DOI：
10.1016/j.brainresbull.2005.08.015
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发表时间：
2005-12-15
影响因子：
3.8
通讯作者：
Bähr, M
中科院分区：
文献类型：
--
作者：
Dietz, GPH;Bähr, M
在过去的15年里，许多文献描述了多肽序列的使用，这些序列被称为细胞穿透肽(CPP)、特洛伊木马多肽、蛋白质转导结构域或膜转位序列。这些大部分带正电的结构域将附着的货物带过生物膜。人们对CPP感兴趣的原因之一是它们有潜力作为递送工具来增强药物的药效学，否则生物利用度很低。特别是，出于分析或治疗的原因，旨在将蛋白质或其他化合物输送到大脑中的神经科学家面临着一个挑战，即很少有药物能跨越血脑屏障。CPP在基础研究和神经系统疾病的相关模型中是克服质膜或血脑屏障的有价值的工具，有望增加脑和神经系统疾病患者宝贵的少数治疗甚至治愈。在这里，我们回顾了在神经科学中的应用，以及对CPP介导的贩运机制的最新见解。(C)2005 Elsevier Inc.保留所有权利。
Over the last 15 years, many publications described the use of peptide sequences that have been dubbed cell penetrating peptides (CPP), Trojan Horse peptides, protein transduction domains, or membrane-translocating sequences. These mostly positively charged domains bring attached cargo across biological membranes. One of the reasons for the interest in CPP is their potential as delivery tools to enhance the pharmacodynamics of drugs otherwise poorly bioavailable. In particular, the neuroscientist aiming to deliver a protein or other compound into the brain for analytical or therapeutic reasons is faced with the challenge that few drugs cross the blood-brain barrier. CPP are valuable tools to overcome the plasma membrane or the blood-brain barrier in basic research, and in relevant models of neural disease, and will hopefully help to increase the precious few treatments or even cures for people with diseases of the brain and nervous system. Here, we review applications in neuroscience and recent insights into the mechanism of CPP-mediated trafficking. (c) 2005 Elsevier Inc. All rights reserved.