A surface acoustic wave-assisted micromixer with active temperature control
A surface acoustic wave-assisted micromixer with active temperature control
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DOI：
10.1016/j.sna.2022.113833
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发表时间：
2022-08-24
影响因子：
4.6
通讯作者：
Wang, Chaohui
中科院分区：
文献类型：
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作者：
Bai, Cheng;Zhou, Wen;Wang, Chaohui
微流体混合是芯片实验室系统中的一个关键问题，在生物医学领域有着广泛的应用。最近，基于声波的有源微混合器已经被应用于通过声流来提高混合效率。然而，沿着声流，声热效应将产生额外的热量以增加微流体的温度。在这项工作中，我们提出了一个集成的热控制单元应用于表面声波（SAW）辅助微混频器来解决这个问题。在微通道下制作金属微导线作为热电阻传感器，用于测量不同条件下的温度，下面的珀尔帖冷却器可以对微流体进行主动温度控制。为了表征，在该装置上成功地进行了中和反应和碱性磷酸酶测定。结果表明，集成热控制单元应用于SAW辅助微混合器在温度敏感的生物医学研究中是非常有效的。
Microfluidic mixing is a critical issue in the lab-on-a-chip system, which has been applied in various biomedical research. Recently, acoustic wave-based active micromixers have been applied to increase the mixing efficiency via acoustic streaming. However, along with the acoustic streaming, the acoustic thermal effect will generate additional heat to increase the temperature of the microfluid. In this work, we present an integrated thermal control unit applied to a surface acoustic wave (SAW)-assisted micromixer to address this problem. A metal microwire as the thermal resistance sensor is fabricated under the microchannel to measure the temperature in different conditions, together with the Peltier cooler beneath allowing the active temperature control of the microfluid. For characterization, neutralization reaction and alkaline phosphatase assay were successfully conducted on this device. It shows the integrated thermal control unit applied to a SAW-assisted micromixer is highly effective in temperature-sensitive biomedical research.