3-D X-Ray-Induced Acoustic Computed Tomography With a Spherical Array: A Simulation Study on Bone Imaging
3-D X-Ray-Induced Acoustic Computed Tomography With a Spherical Array: A Simulation Study on Bone Imaging
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DOI：
10.1109/tuffc.2020.2983732
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发表时间：
2020-08-01
影响因子：
3.6
通讯作者：
Xiang, Liangzhong
中科院分区：
文献类型：
--
作者：
Li, Yang;Samant, Pratik;Xiang, Liangzhong
x射线诱发声计算机断层扫描（XACT）是一种很有前途的成像方式，结合了高x射线吸收对比度和高分辨率超声波提供的三维传播优势。本研究的目的是优化用于骨成像的三维XACT成像系统的配置。设计了一种峰值频率为10MHz的280超声传感器分布在球面上，以优化三维体成像能力。我们对这种优化的XACT成像配置进行了理论计算和模拟，模拟对象是一个鼠标大小的数字模型，其中包含各种x射线吸收系数。基于全变分的迭代算法被用于三维XACT图像重建。成像的空间分辨率沿轴向和横向估计约为130 μ m。我们使用由真实生物样本的微ct图像生成的数字幻影模拟XACT骨微结构成像，表明XACT成像可以提供小鼠爪子的高分辨率成像。本研究的结果将极大地提高XACT成像在骨疾病评估中的潜力，以供将来的临床应用。
X-ray-induced acoustic computed tomography (XACT) is a promising imaging modality combining high X-ray absorption contrast with the 3-D propagation advantages provided by high-resolution ultrasound waves. The purpose of this study was to optimize the configuration of a 3-D XACT imaging system for bone imaging. A 280 ultrasonic sensorswith peak frequency of 10MHz was designed to distribute on a spherical surface to optimize the 3-D volumetric imaging capability. We performed both theoretical calculations and simulations of this optimized XACT imaging configuration on a mouse-sized digital phantom containing various X-ray absorption coefficients. Iteration algorithm based on total variation has been used for 3-D XACT image reconstruction. The spatial resolution of imaging was estimated to about 130 mu m along both axial and lateral directions. We simulate XACT imaging of bone microstructures using digital phantoms generated from micro-CT images of real biological samples, showing that XACT imaging can provide high-resolution imaging of the mouse paw. Results of this study will greatly enhance the potential of XACT imaging in the evaluation of bone diseases for future clinical use.