Vasopressin and oxytocin receptor systems in the brain: Sex differences and sex-specific regulation of social behavior.
Vasopressin and oxytocin receptor systems in the brain: Sex differences and sex-specific regulation of social behavior.
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DOI：
10.1016/j.yfrne.2015.04.003
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发表时间：
2016-01
影响因子：
7.4
通讯作者：
Veenema AH
中科院分区：
文献类型：
--
作者：
Dumais KM;Veenema AH
脑中的神经肽血管加压素（VP）和催产素（OT）及其受体参与各种社会行为的调节，并已成为治疗几种性别偏见神经精神障碍中社会功能障碍的药物靶点。因此，VP和OT系统的性别差异可能与健康和受损的社会行为的性别特异性调节有关。我们开始这个审查强调性别差异，或缺乏性别差异，在VP和OT合成在大脑中。然后，我们讨论的证据表明存在或不存在的VP和OT受体在啮齿动物和人类的性别差异，以及显示性二态V1a受体结合在大鼠大脑中的新数据。重要的是，我们发现，在常见的实验室物种中，缺乏对这些系统中性别差异的全面分析，我们发现，当存在性别差异时，它们具有高度的大脑区域和物种特异性。有趣的是，VP系统参数（VP和V1 aR）在男性中通常更高，而OT系统的性别差异并不总是在同一方向，通常显示女性中OT表达更高，但男性中OT受体表达更高。此外，VP和OT受体系统在啮齿动物脑中显示出不同的且在很大程度上不重叠的表达，这可能导致这些受体在社会行为的性别特异性调节中具有互补或相反的功能作用。虽然仍然需要进一步的研究，我们关闭讨论如何操纵VP和OT系统提供了重要的见解，这些神经肽系统的参与在啮齿动物和人类的社会行为的性别特异性调节。
The neuropeptides vasopressin (VP) and oxytocin (OT) and their receptors in the brain are involved in the regulation of various social behaviors and have emerged as drug targets for the treatment of social dysfunction in several sex-biased neuropsychiatric disorders. Sex differences in the VP and OT systems may therefore be implicated in sex-specific regulation of healthy as well as impaired social behaviors. We begin this review by highlighting the sex differences, or lack of sex differences, in VP and OT synthesis in the brain. We then discuss the evidence showing the presence or absence of sex differences in VP and OT receptors in rodents and humans, as well as showing new data of sexually dimorphic V1a receptor binding in the rat brain. Importantly, we find that there is lack of comprehensive analysis of sex differences in these systems in common laboratory species, and we find that, when sex differences are present, they are highly brain region- and species- specific. Interestingly, VP system parameters (VP and V1aR) are typically higher in males, while sex differences in the OT system are not always in the same direction, often showing higher OT expression in females, but higher OT receptor expression in males. Furthermore, VP and OT receptor systems show distinct and largely non-overlapping expression in the rodent brain, which may cause these receptors to have either complementary or opposing functional roles in the sex-specific regulation of social behavior. Though still in need of further research, we close by discussing how manipulations of the VP and OT systems have given important insights into the involvement of these neuropeptide systems in the sex-specific regulation of social behavior in rodents and humans.