INTRAVASCULAR LARGE CELL LYMPHOMA - DIAGNOSIS ON RENAL BIOPSY
INTRAVASCULAR LARGE CELL LYMPHOMA - DIAGNOSIS ON RENAL BIOPSY
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DOI：
10.3109/00313029109063574
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发表时间：
1991-07-01
期刊：
影响因子：
4.5
通讯作者：
HORN, M
中科院分区：
文献类型：
--
作者：
AXELSEN, RA;LAIRD, PP;HORN, M
该病例报告了一名60岁的妇女，她出现全身症状，发现每天蛋白尿3.5 g。 肾活检显示大量的肿瘤细胞填充许多肾小球毛细血管腔。 免疫组化染色显示，恶性细胞的表型为LCA +、L26 +、MB 2+、UCHL 1-、CD 43-、CAM 5.2-和S100-，表明其为淋巴源性B细胞系。 诊断为血管内大细胞淋巴瘤。 用CAVP（环磷酰胺、阿霉素、长春新碱和泼尼松）化疗诱导缓解。 随后的复发用环磷酰胺、VP 16和泼尼松治疗，再次出现缓解。 这是作者所知的第一例肾活检诊断为血管内大细胞淋巴瘤。 我们证实了其他人的经验，化疗方案用于其他品种的大细胞淋巴瘤也可能是适当的这种不寻常的肿瘤。
The case is reported of a woman aged 60 yrs who presented with systemic symptoms and who was found to have proteinuria of 3.5 g per day. A renal biopsy revealed numerous neoplastic cells filling many of the glomerular capillary lumina. Immunoperoxidase stains revealed that the phenotype of the malignant cells was LCA +, L26 +, MB2 +, UCHL1-, CD43-, CAM5.2- AND S100-, indicating that they were of lymphoid origin and B-cell lineage. The diagnosis of intravascular large cell lymphoma was therefore made. Remission was induced by chemotherapy with CAVP (cyclophosphamide, adriamycin, vincristine and prednisone). A subsequent relapse was treated with cyclophosphamide, VP 16 and prednisone, and again remission occurred. This is the first case known to the authors in which the diagnosis of intravascular large cell lymphoma was made on renal biopsy. We confirm the experience of others that chemotherapy with regimens utilized in other varieties of large cell lymphoma may also be appropriate for this unusual neoplasm.