Effect of thyroid hormones on oxidative and nonoxidative glucose metabolism in humans.
Effect of thyroid hormones on oxidative and nonoxidative glucose metabolism in humans.
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DOI：
10.1152/ajpendo.1988.255.2.e146
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发表时间：
1988-08
期刊：
影响因子：
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通讯作者：
M. Müller;K. Acheson;E. Jéquier;A. Burger
中科院分区：
文献类型：
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作者：
M. Müller;K. Acheson;E. Jéquier;A. Burger
在 6 名健康受试者中，在 3,5,3',5'-四碘甲状腺原氨酸 (T4) 治疗（300 微克/天）14 天之前和之后，在正常血糖（0-2 小时）和高血糖（165 mg/dl，2-5 小时）和不同胰岛素输注速率（1.0 0-3.5 小时和 6.5 mU.kg-1.min-1，持续 3.5-5 小时）。 T4处理增加了基础能量消耗（+8%）、葡萄糖处理（+31%）和氧化（+87%），但降低了非氧化葡萄糖代谢（-30%），并且对脂质氧化没有影响。在正常血糖钳夹期间，T4 治疗增强了胰岛素诱导的葡萄糖处理（+16%）、葡萄糖氧化（+34%）和脂质氧化抑制（-66 vs. -40%）； T4前后非氧化葡萄糖代谢受到相似程度的刺激。在高血糖期间，3,5,3'-三碘甲状腺原氨酸 (T3) 不会影响葡萄糖的处理，但在两种胰岛素输注速率下都会增加碳水化合物诱导的脂肪生成。我们得出结论，T4 治疗促进葡萄糖处理和氧化，T3 减少非胰岛素介导的葡萄糖储存，但不拮抗胰岛素作用。
The glucoregulatory function of thyroid hormones was investigated in six healthy subjects before and after 14 day 3,5,3',5'-tetraiodothyronine (T4) treatment (300 micrograms/day) using a sequential clamp protocol for 5 h at euglycemia (0-2 h) and hyperglycemia (165 mg/dl, 2-5 h) and different insulin infusion rates (1.0 for 0-3.5 h and 6.5 mU.kg-1.min-1, for 3.5-5 h). T4 treatment increased basal energy expenditure (+8%), glucose disposal (+31%), and oxidation (+87%) but decreased nonoxidative glucose metabolism (-30%) and was without effect on lipid oxidation. During the euglycemic clamp, T4 treatment enhanced insulin-induced glucose disposal (+16%), glucose oxidation (+34%), and inhibition of lipid oxidation (-66 vs. -40%); nonoxidative glucose metabolism was stimulated to a similar extent before and after T4. During hyperglycemia, 3,5,3'-triiodothyronine (T3) did not affect glucose disposal but increased carbohydrate-induced lipogenesis at both insulin infusion rates. We conclude that T4 treatment promotes glucose disposal and oxidation, T3 decreases noninsulin-mediated glucose storage but does not antagonize insulin action.