The Pneumococcus: Epidemiology, Microbiology, and Pathogenesis
The Pneumococcus: Epidemiology, Microbiology, and Pathogenesis
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DOI：
10.1101/cshperspect.a010215
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发表时间：
2013-07-01
影响因子：
5.4
通讯作者：
Tuomanen, Elaine I.
中科院分区：
文献类型：
--
作者：
Henriques-Normark, Birgitta;Tuomanen, Elaine I.
肺炎球菌是典型的革兰氏阳性细胞外病原体。它引起的疾病的医疗负担是世界上最大的。100多年来的深入研究已经对其生理学，发病机制和免疫力的基本方面有所了解。控制感染的努力导致了多糖疫苗的部署和对抗生素耐药性的理解。肺炎球菌的炎症反应是医学上最有效的反应之一，它揭示了清除感染的双刃剑，但以损害宿主细胞为代价。几乎在感染过程的每一个方面，肺炎球菌都制定了革兰氏阳性菌致病的游戏规则。
The pneumococcus is the classic Gram-positive extracellular pathogen. The medical burden of diseases it causes is amongst the greatest in the world. Intense study for more than 100 years has yielded an understanding of fundamental aspects of its physiology, pathogenesis, and immunity. Efforts to control infection have led to the deployment of polysaccharide vaccines and an understanding of antibiotic resistance. The inflammatory response to pneumococci, one of the most potent in medicine, has revealed the double-edged sword of clearance of infection but at a cost of damage to host cells. In virtually every aspect of the infectious process, the pneumococcus has set the rules of the Gram-positive pathogenesis game.