INSULIN AS AN AMYLOID-FIBRIL PROTEIN AT SITES OF REPEATED INSULIN INJECTIONS IN A DIABETIC PATIENT
INSULIN AS AN AMYLOID-FIBRIL PROTEIN AT SITES OF REPEATED INSULIN INJECTIONS IN A DIABETIC PATIENT
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DOI：
10.1007/bf00276849
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发表时间：
1988-03-01
期刊：
影响因子：
8.2
通讯作者：
WATKINS, PJ
中科院分区：
文献类型：
--
作者：
DISCHE, FE;WERNSTEDT, C;WATKINS, PJ
1例1型（胰岛素依赖型）糖尿病患者在注射猪胰岛素的部位发生了局部淀粉样变性。提取了一种主要的淀粉样原纤维蛋白，通过其氨基酸组成和氨基酸序列，表明其含有完整的胰岛素分子。猪胰岛素是人类淀粉样纤维中第十种蛋白质，也是第一种被化学鉴定的外源蛋白质。
A patient with Type 1 (insulin-dependent) diabetes mellitus developed localized amyloidosis at the sites of his injections of porcine insulin. A major amyloid fibril protein was extracted and, by means of its amino acid composition and amino acid sequence, it was shown to contain intact insulin molecules. Porcine insulin is the tenth protein and the first foreign protein to be chemically identified in human amyloid fibrils.