THE ROLE OF MHC AND NON-MHC ANTIGENS IN THE REJECTION OF INTRACEREBRAL ALLOGENEIC NEURAL GRAFTS

THE ROLE OF MHC AND NON-MHC ANTIGENS IN THE REJECTION OF INTRACEREBRAL ALLOGENEIC NEURAL GRAFTS
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DOI:
10.1097/00007890-198912000-00025
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发表时间:
1989-12-01
期刊:
影响因子:
6.2
通讯作者:
GILL, TJ
GILL, TJ
中科院分区:
医学2区
文献类型:
--
作者:
RAO, K;LUND, RD;GILL, TJ

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Embryonic DA retinal allografts that have survived for prolonged periods after having been transplanted into the brains of neonatal BN rats can be induced to reject following peripheral sensitization with a DA skin graft. The results show that histocompatibility antigens play the major role in the rejection of grafts placed in the CNS and that a disparity between the retinal and skin grafts for MHC antigens induces a more severe rejection response than does a non-MHC antigen disparity.