Incidence of cervical cancer after several negative smear results by age 50: prospective observational study
Incidence of cervical cancer after several negative smear results by age 50: prospective observational study
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DOI：
10.1136/bmj.b1354
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发表时间：
2009-04-24
影响因子：
105.7
通讯作者：
Habbema, Dik
中科院分区：
文献类型：
--
作者：
Rebolj, Matejka;van Ballegooijen, Marjolein;Habbema, Dik
目的了解不同年龄段多次宫颈涂片阴性后宫颈癌的发病率。设计基于国家组织病理学和细胞病理学登记处（PALGA）个体水平数据的连续第三次阴性结果后宫颈癌发病率的前瞻性观察研究。全国数据：45-54岁妇女218 847人，30- 54岁妇女445 382人结果105名妇女在2595964妇女年内发生宫颈癌，其中105名妇女在2595964妇女年内发生宫颈癌，105名妇女在259964妇女年内发生宫颈癌，105名妇女在2595964妇女年内发生宫颈癌在30-44岁和42岁的第三次阴性结果后的风险在45-54岁后的1 278 532个妇女年的风险。在随访期间，两个年龄组的筛查水平相似。随访10年后，宫颈癌的累积发病率相似：年轻组为41/100 000（95%置信区间33至51），老年组为36/100 000（24至52）（P=0.48）。年轻组宫颈上皮内瘤变I+级的累积发病率是老年组的2倍（P
Objective To determine the incidence of cervical cancer after several negative cervical smear tests at different ages.Design Prospective observational study of incidence of cervical cancer after the third consecutive negative result based on individual level data in a national registry of histopathology and cytopathology (PALGA).Setting Netherlands, national data.Population 218 847 women aged 45-54 and 445 382 aged 30-44 at the time of the third negative smear test.Main outcome measures 10 year cumulative incidence of interval cervical cancer.Results 105 women developed cervical cancer within 2 595 964 woman years at risk after the third negative result at age 30-44 and 42 within 1 278 532 woman years at risk after age 45-54. During follow-up, both age groups had similar levels of screening. After 10 years of follow-up, the cumulative incidence rate of cervical cancer was similar: 41/100 000 (95% confidence interval 33 to 51) in the younger group and 36/100 000 (24 to 52) in the older group (P=0.48). The cumulative incidence rate of cervical intraepithelial neoplasia grade I+ was twice as high in the younger than in the older group (P