Coding of Reward Risk by Orbitofrontal Neurons Is Mostly Distinct from Coding of Reward Value
Coding of Reward Risk by Orbitofrontal Neurons Is Mostly Distinct from Coding of Reward Value
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DOI：
10.1016/j.neuron.2010.09.031
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发表时间：
2010-11-18
期刊：
影响因子：
16.2
通讯作者：
Schultz, Wolfram
中科院分区：
文献类型：
--
作者：
O'Neill, Martin;Schultz, Wolfram
在人类和动物中，眶额皮质受损会改变风险决策。然而，完整的眶额皮质在处理与风险决策相关的信息中的细胞功能是未知的。我们记录了猴子观察代表关键决策参数、奖励风险和价值的视觉线索时单个眶额神经元的反应。风险被定义为奖励幅度的二进制对称概率分布的数学方差;价值被定义为非风险奖励幅度。猴子表现出对风险结果的分级行为偏好，就像它们对价值的偏好一样。一个人口的眶额神经元表现出独特的风险信号：他们的线索和奖励反应单调变化的方差不同的奖励分布没有单调编码奖励值。此外，一小部分风险应对措施也编码了奖励价值，但在统计学上很重要。这些风险信号可以提供生理相关的眶额皮质在风险处理中的作用。
Risky decision-making is altered in humans and animals with damage to the orbitofrontal cortex. However, the cellular function of the intact orbitofrontal cortex in processing information relevant for risky decisions is unknown. We recorded responses of single orbitofrontal neurons while monkeys viewed visual cues representing the key decision parameters, reward risk and value. Risk was defined as the mathematical variance of binary symmetric probability distributions of reward magnitudes; value was defined as nonrisky reward magnitude. Monkeys displayed graded behavioral preferences for risky outcomes, as they did for value. A population of orbitofrontal neurons showed a distinctive risk signal: their cues and reward responses covaried monotonically with the variance of the different reward distributions without monotonically coding reward value. Furthermore, a small but statistically significant fraction of risk responses also coded reward value. These risk signals may provide physiological correlates for the role of the orbitofrontal cortex in risk processing.