Argonautes compete for miR165/166 to regulate shoot apical meristem development.

Argonautes compete for miR165/166 to regulate shoot apical meristem development.
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DOI:
10.1016/j.pbi.2012.05.007
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发表时间:
2012-12
影响因子:
9.5
通讯作者:
Zhang X
Zhang X
中科院分区:
生物学2区
文献类型:
--
作者:
Zhang Z;Zhang X

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茎尖分生组织(SAM)中的植物干细胞具有独特的能力,既可以自我更新以维持SAM,又可以为气生器官的启动和后续发育提供未分化的子细胞。器官发生过程中干细胞更新和细胞分化之间的协调受到涉及大量转录因子和其他分子的复杂遗传途径的调节。在过去的十年中,microRNA (miRNA) 已成为许多生物过程中的关键调节因子,包括植物分生组织稳态和分化。在这篇综述中,我们总结了目前关于 miRNA 家族 (miR165/166)、miRNA 指定的 Argonautes (AGO) 以及 SAM 发育和维护中 miRNA 调控靶标的功能和机制的知识。
Plant stem cells in the shoot apical meristem (SAM) possess the unique abilities of both self-renewal for SAM maintenance and providing undifferentiated daughter cells for initiation and subsequent development of aerial organs. The coordination between stem cell renewal and cell differentiation during organogenesis is regulated by elaborate genetic pathways involving numerous transcription factors and other molecules. In the past decade, microRNAs (miRNAs) have emerged as pivotal regulators in many biological processes including meristem homeostasis and differentiation in plants. In this review, we summarize current knowledge about the function and mechanism of a family of miRNAs (miR165/166), the miRNA-designated Argonautes (AGOs), and the miRNA-regulated targets in SAM development and maintenance.
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