Itch-associated responses of afferent nerve innervating the murine skin: different effects of histamine and serotonin in ICR and ddY mice.
Itch-associated responses of afferent nerve innervating the murine skin: different effects of histamine and serotonin in ICR and ddY mice.
复制标题
支配小鼠皮肤的传入神经的瘙痒相关反应：组胺和血清素对 ICR 和 ddY 小鼠的不同影响。
DOI：
10.1254/jjp.84.462
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发表时间：
2000
期刊：
影响因子：
--
通讯作者：
Y. Kuraishi
中科院分区：
文献类型：
--
作者：
T. Maekawa;H. Nojima;Y. Kuraishi
为了评价支配小鼠皮肤的初级传入神经在体内的瘙痒相关反应，比较了皮内注射组胺和5-羟色胺对ICR和ddy小鼠的瘙痒反应和皮肤神经放电反应的量效曲线和时程。5-羟色胺增加了ICR或ddy小鼠的瘙痒-抓挠反应和皮肤神经放电。组胺增加了ICR小鼠的这两种反应，但不能增加ddy小鼠的这两种反应。5-羟色胺和组胺诱发的神经放电的剂量-反应曲线和时间过程与瘙痒-抓挠反应相似。结果表明，外周给药引起的皮肤神经放电包括瘙痒相关反应。
To assess the itch-associated response of primary afferents innervating the murine skin in vivo, dose-response curves and time-courses for itch-scratching and cutaneous nerve firing responses to intradermal injections of pruritogens (histamine and serotonin) were compared in ICR and ddY mice. Serotonin increased the itch-scratch response and cutaneous nerve firing in either ICR or ddY mice. Histamine increased these two responses in ICR, but not ddY, mice. The dose-response curves and time-courses for serotonin- and histamine-induced nerve firing were similar to those for the itch-scratch response. The results suggest that cutaneous nerve firing evoked by peripherally given pruritogens includes the itch-associated response.
4-碘托莫西汀：血清素吸收位点的新型配体。
影响因子：
6.1
作者：
Kung,MP;Chumpradit,S;Billings,J;Kung,H
通讯作者：
Kung,H