The dentine disc. A review of its applicability as a model for the in vitro testing of dentine hypersensitivity.
The dentine disc. A review of its applicability as a model for the in vitro testing of dentine hypersensitivity.
复制标题
牙本质盘。
DOI：
10.1111/j.1365-2842.1997.tb00308.x
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发表时间：
1997
影响因子：
2.9
通讯作者：
D. Gillam
中科院分区：
文献类型：
--
作者：
N. Mordan;P. Barber;D. Gillam
牙本质盘已被广泛用作通过扫描电子显微镜(SEM)在体外评估潜在脱敏剂的模型。虽然圆盘提供了一个容易获得和可重现的测试基板，但本文解决了与此模型相关的问题，如牙本质小管的自然变异和由此导致的表面形态差异。在超微结构水平上，单个蚀刻盘的表面表现出切割的牙本质小管的大小、密度、取向和蚀刻程度的变化。在本研究中，设计了一种精确的控制程序，允许测试表面和控制表面之间有更大的相关性。使用同一圆盘的两个相邻区域，一个作为测试表面，另一个作为对照。使用这种方法检查了两种专有脱敏剂。这项研究表明，牙本质盘是一种良好的、可靠的模型，用于体外筛选和测试潜在的脱敏剂，前提是应用这样的对照。
The dentine disc has been extensively used as a model for assessing potential desensitizing agents in vitro by scanning electron microscopy (SEM). Although the disc provides a readily available and reproducible test substrate, this paper addresses the problems associated with this model such as the natural variation in the dentine tubules and the resulting differences in surface morphology. At the ultrastructural level the surface of a single etched disc exhibits variations in the size, density, orientation and extent of etching of the cut dentine tubules. In the present study a precise control procedure was designed which allowed greater correlation between test and control surfaces. Two adjacent areas of the same disc were used, one as the test surface, the other the control. Two proprietary desensitizers were examined using this methodology. This study has shown that the dentine disc is a good, reliable model for in vitro screening and testing of potential desensitizing agents, providing such controls are applied.
影响因子：
4.3
作者：
D. Pashley;J. G. Leibach;J. Horner
通讯作者：
D. Pashley;J. G. Leibach;J. Horner