Familial brain tumours -: Genetics or environment?: A nationwide cohort study of cancer risk in spouses and first-degree relatives of brain tumour patients
Familial brain tumours -: Genetics or environment?: A nationwide cohort study of cancer risk in spouses and first-degree relatives of brain tumour patients
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DOI：
10.1002/ijc.11213
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发表时间：
2003-08-20
影响因子：
6.4
通讯作者：
Grönberg, H
中科院分区：
文献类型：
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作者：
Malmer, B;Henriksson, R;Grönberg, H
我们的研究调查了胶质瘤的家族聚集是否是由于环境或遗传效应，并调查和比较了原发性脑肿瘤（PBT）患者的配偶和一级亲属（FDR）发展PBT和其他类型癌症的风险。瑞典癌症登记处（SCR）从1968年至1997年在瑞典确定的所有PBT患者都与全国范围的瑞典家庭数据库相关联，包括1932年至1997年出生的瑞典人。配偶和FDR的队列与SCR相关联，以确定观察到的PBT和其他癌症病例。使用SCR的发生率作为参考，计算标准化发生率比（SIR）。我们发现，在配偶队列中，任何特定类型的PBT的风险都没有增加。在FDR队列中，对于与先证者相同的组织病理学，PBT的风险通常显著增加2至3倍。PBT患者的配偶患皮肤癌的风险增加。我们的结论是，罗斯福，而不是配偶，有一个显着增加的风险，这表明一个遗传起源的家族聚集性脑肿瘤。(C)2003 Wiley-Liss，Inc.
Our study investigated whether the familial aggregation of glioma is due to environmental or genetic effects and it investigated and compared the risk to spouses and first-degree relatives (FDR) of patients with primary brain tumours (PBT) for developing both PBT and the risk for other types of cancer. All PBT patients identified in Sweden from 1968-97 in The Swedish Cancer Registry (SCR) were linked to the nationwide Swedish Family Database, including persons in Sweden born from 1932-97. The cohorts of spouses and FDR were linked to the SCR to identify observed cases of PBT and other cancer. Standardised incidence ratios (SIR) were calculated using the incidence rates from SCR as the reference. We found that there were no increased risks for any specific type of PBT in the cohort of spouses. In the FDR cohort, generally the risk for a PBT was significantly increased by 2 to 3 times for the same histopathology as the probands. Spouses of PBT patients had an increased risk of skin cancer. We conclude that FDR, not spouses, have a significantly increased risk, which indicates a genetic origin of the familial aggregation of brain tumours. (C) 2003 Wiley-Liss, Inc.