Effect of vitamin D on biochemical parameters in polycystic ovary syndrome women: a meta-analysis
Effect of vitamin D on biochemical parameters in polycystic ovary syndrome women: a meta-analysis
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维生素 D 对多囊卵巢综合征女性生化参数的影响：荟萃分析
DOI：
10.1007/s00404-016-4247-y
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发表时间：
2017-02-01
影响因子：
2.6
通讯作者：
Gu, Lin
中科院分区：
文献类型：
--
作者：
Xue, Yunping;Xu, Pengfei;Gu, Lin
目的探讨维生素D补充对PCOS患者代谢和内分泌参数的治疗作用。材料与方法通过检索PubMed、Embase、The科克伦图书馆和Web of Science，选择2016年4月之前有关维生素D补充对PCOS患者治疗作用的临床研究。根据纳入标准选择纳入文献。检测PCOS患者血清HOMA-IR、QUICKI、LDL、DHEAS、游离睾酮（FT）、总睾酮（TT）、甲状旁腺素（PTH）、25-羟维生素D（25-hydroxy-vitamin D）、甘油三酯（TG）水平，评价维生素D治疗PCOS的疗效。PCOS患者血清25-羟基维生素D浓度在安慰剂组和维生素D组之间差异无统计学意义（P= 0.06）。维生素D治疗后，PCOS患者血清25-羟维生素D水平升高（P< 0.00001），血清甲状旁腺素（P= 0.003）和甘油三酯（P= 0.006）水平降低。PCOS患者血清HOMA-IR、QUICKI、LDL、DHEAS、FT、TT无明显变化。亚组分析显示，小剂量补充维生素D可降低PCOS患者的血清甘油三酯（<50，000 IU）（P= 0.03），但高剂量维生素D补充剂没有显著改变（≥ 50，000 IU）结论补充维生素D可显著降低PCOS患者血清PTH和甘油三酯水平，但HOMA-IR、QUICKI、LDL、DHEAS、FT和TT。此外，少于50，000 IU的维生素D补充足以降低血清甘油三酯。
AimTo investigate the therapeutical effect of vitamin D supplementation on the metabolism and endocrine parameters of PCOS patients.Materials and methodsClinical studies investigating the therapeutic effect of vitamin D supplementation on PCOS patients were selected by searching PubMed, Embase, The Cochrane library and Web of Science until April 2016. The included articles were selected according to the inclusion criteria. Serum HOMA-IR, QUICKI, LDL, DHEAS, free testosterone (FT), total testosterone (TT), PTH, 25-hydroxy-vitamin D, and triglyceride of PCOS patients were enrolled for evaluating the therapeutic effects of vitamin D.Results16 studies were included in this study. There was no significant difference between the placebo group and vitamin D group in the concentration of serum 25-hydroxy-vitamin D in patients with PCOS (P= 0.06). After treated with vitamin D, the serum 25-hydroxy-vitamin D in PCOS patients was increased (P< 0.00001), while the serum PTH (P= 0.003) and triglyceride (P= 0.006) were decreased. In addition, the serum HOMA-IR, QUICKI, LDL, DHEAS, FT, and TT in PCOS patients did not change. Subgroup analysis showed that the serum triglyceride of PCOS patients was decreased by low dose of vitamin D supplementation (<50,000 IU) (P= 0.03), but no significantly changed by high-dose vitamin D supplementation (≥50,000 IU) (P= 0.17).ConclusionVitamin D supplementation significantly attenuates serum PTH and triglyceride in PCOS patients except for serum HOMA-IR, QUICKI, LDL, DHEAS, FT, and TT. Furthermore, less than 50,000 IU vitamin D supplementation is sufficient for decreasing serum triglyceride.