Gastritis staging in clinical practice: the OLGA staging system
Gastritis staging in clinical practice: the OLGA staging system
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DOI：
10.1136/gut.2006.106666
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发表时间：
2007-05-01
期刊：
影响因子：
24.5
通讯作者：
Graham, David Y.
中科院分区：
文献类型：
--
作者：
Rugge, Massimo;Meggio, Alberto;Graham, David Y.
背景：现有的胃炎分类使用不一致，可能是因为没有一种分类能为临床医生提供即时的预后/治疗信息。由于肝炎分期的组织学报告在临床上是有用的并被广泛接受，一个国际组织(OLGA)提出了一个等效的胃组织学分期系统来报告胃组织学。胃炎分期结合萎缩评分(通过活检获得)和萎缩形态(通过定向活检标测获得)。目的：在前瞻性横断面研究中，检验Olga分期是否一致地根据患者的癌症风险对患者进行分层，并提供明确的预后/治疗信息。方法：对439例前瞻性入选的连续消化不良门诊患者进行Olga胃癌风险(O-IV)分期和胃炎分级(炎性浸润物总分，1-4级)。意外的肿瘤损害和共存的消化性溃疡被记录下来。结果：良性病变(包括十二指肠溃疡)和幽门螺杆菌感染状态(如A=3；C=2；Hp+Ve)。
Background: The available classifications of gastritis are inconsistently used, possibly because none provides immediate prognostic/therapeutic information to clinicians. As histology reporting of hepatitis in terms of stage is clinically useful and widely accepted, an international group (Operative Link on Gastritis Assessment (OLGA)) proposed an equivalent staging system for reporting gastric histology. Gastritis staging integrates the atrophy score (obtained by biopsy) and the atrophy topography (achieved through directed biopsy mapping).Aim: To test in a prospective cross-sectional study whether OLGA staging consistently stratified patients according to their cancer risk and provided clear prognostic/therapeutic information.Methods: OLGA staging for gastric cancer risk (O-IV) and gastritis grading (overall score of the inflammatory infiltrate, grade 1-4) were applied in 439 prospectively enrolled, consecutive, dyspeptic outpatients who underwent endoscopy with standardised biopsy sampling. Incidental neoplastic lesions and coexisting peptic ulcers were recorded. Results were presented as stage (including antral (A) and corpus (C) atrophy scores) and H pylori status (eg, A = 3; C = 2: stage IV; Hp+ve).Results: Benign conditions (including duodenal ulcers; p