Increases in ethanol ingestion by young rats following interaction with intoxicated siblings: a review.
Increases in ethanol ingestion by young rats following interaction with intoxicated siblings: a review.
复制标题
幼鼠与中毒的兄弟姐妹互动后乙醇摄入量增加：综述。
DOI：
10.1007/bf02734096
复制
发表时间：
2001
期刊：
影响因子：
--
通讯作者：
Hallmark,RA
中科院分区：
文献类型：
--
作者：
Hunt,PS;Hallmark,RA
尽管酒精中毒研究中使用了多种动物模型，但很少有实验调查可能导致初次饮酒的环境/经验因素。青少年酒精滥用是当今社会的一个主要问题，研究开始关注酒精消费的易感条件，特别是在这个脆弱的年龄组。我们实验室最近的研究结果回顾了断奶前和青春期大鼠在暴露于醉酒的兄弟姐妹后自愿摄入乙醇的情况。这一范式的核心是啮齿动物，也许还有其他哺乳动物物种，在一定程度上是基于与最近摄入了一种新饮食的同种动物的相互作用而获得关于摄入食物的信息（例如Galef， 1981）。从另一种动物的呼吸中闻到食物来源的线索，已知会影响后来的食物选择。本文中描述的程序代表了一种潜在的新模型，用于检查通过社会互动早期接触乙醇对开始自愿饮酒的影响。
Although there are a variety of animal models used in alcoholism research, there has been very little experimental investigation into possible environmental/experiential factors leading to an initial bout of alcohol ingestion. Adolescent alcohol abuse is a major problem in today's society and research is beginning to focus on the predisposing conditions toward alcohol consumption, particularly in this vulnerable age group. The results of recent research from our laboratory are reviewed in which voluntary ingestion of ethanol by preweanling and adolescent rats is increased following exposure to an intoxicated sibling. This paradigm centers on the notion that rodents, and perhaps other mammalian species as well, acquire information about foods to ingest based in part on interaction with a conspecific that has recently ingested a novel diet (e.g. Galef, 1981). Smelling food-derived cues on the breath of another animal is known to affect later food choice. The procedures described in this paper represent a potential new model for examining the effects of early exposure to ethanol through social interactions on the initiation of voluntary alcohol ingestion.