Studies on the pharmacokinetics of primaquine.
Studies on the pharmacokinetics of primaquine.
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伯氨喹的药代动力学研究。
DOI：
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发表时间：
1981
影响因子：
11.1
通讯作者：
T. Harinasuta
中科院分区：
文献类型：
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作者：
K. Fletcher;D. Evans;Gilles Hm;J. Greaves;D. Bunnag;T. Harinasuta
建立了一种灵敏、特异的气相色谱-质谱法测定血浆和尿中伯喹的方法，并用于伯喹的血浆动力学研究。对单次和多次口服的效果进行了初步研究。在这两种情况下，药物在24小时内从血浆中完全或几乎完全清除。伯喹的血浆浓度通常在口服后1-2小时达到峰值。血浆消除半衰期约为4小时。在服药后24小时内收集的尿液中检测到不到1%的剂量。当高加索人志愿者同时服用伯氨喹和氯喹时，其中一些人出现了明显的高铁血红蛋白血症。在每天给药后24小时，任何志愿者的血浆中都检测不到伯氨喹。
A sensitive and specific assay for primaquine in plasma and urine using gas chromatography/mass spectrometry has been developed and used to study the plasma kinetics of primaquine. Preliminary studies on the effects of single and multiple oral doses have been carried out. In both cases the drug was completely, or almost completely, removed from the plasma in 24 h. The concentration of primaquine in the plasma usually reached a peak 1-2 hours after oral administration. The plasma elimination half-life was about 4 h. Less than 1% of the dose was detected in the urine collected over a 24-h period following drug ingestion. When Caucasian volunteers were given primaquine and chloroquine concurrently, some of them developed significant methaemoglobinaemia. Primaquine was not detectable in the plasma of any of the volunteers, 24 h after each daily dose.