Immune Response at the Crossroads of Atherosclerosis and Alzheimer's Disease.
Immune Response at the Crossroads of Atherosclerosis and Alzheimer's Disease.
复制标题
DOI：
10.3389/fcvm.2022.870144
复制
发表时间：
2022
影响因子：
3.6
通讯作者：
中科院分区：
文献类型：
--
作者：
阿尔茨海默氏病（AD）和心血管疾病（CVD）是以随着衰老而加速的血管功能障碍和慢性炎症的共同特征为特征的病理。重要的是，流行病学研究报告了AD和CVD之间的独立相互作用，数据表明CVD中的慢性炎症可能加速AD的发展。动脉粥样硬化影响大多数大中型动脉，包括供应脑循环的动脉。由动脉粥样硬化引起的血管功能障碍导致血脑屏障破坏、炎症、淀粉样蛋白-β（Aβ）的清除受损，并且最终以神经血管功能障碍结束。大量数据表明，先天性和适应性免疫反应形成动脉粥样硬化，越来越多的证据表明免疫反应在AD进展中的意义。目前，这两种疾病相互关联的机制尚未明确。在这篇综述中，我们讨论了最近的进展，我们的理解交织在一起的作用，免疫反应在动脉粥样硬化和AD和这些发现对人类健康的影响。
Alzheimer's disease (AD) and cardiovascular disease (CVD) are pathologies that are characterized by common signatures of vascular dysfunction and chronic inflammation that are accelerated with aging. Importantly, epidemiological studies report an independent interaction between AD and CVD and data suggest that chronic inflammation in CVD may accelerate AD development. Atherosclerosis affects most large to medium sized arteries including those supplying the cerebral circulation. Vascular dysfunction caused by atherosclerosis results in blood brain barrier breakdown, inflammation, an impaired clearance of amyloid-beta (Aβ), and finally ends with neurovascular dysfunction. Numerous data indicate that innate and adaptive immune responses shape atherogenesis and increasing evidence suggests an implication of the immune response in AD progression. Currently, mechanisms by which these two diseases are interconnected with each other are not well-defined. In this review, we discuss the recent advances in our understanding of the intertwined role of the immune response in atherosclerosis and AD and the implications of these findings for human health.