Prevalence of age-related macular degeneration in 4 racial/ethnic groups in the multi-ethnic study of atherosclerosis
Prevalence of age-related macular degeneration in 4 racial/ethnic groups in the multi-ethnic study of atherosclerosis
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DOI：
10.1016/j.ophtha.2005.12.013
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发表时间：
2006-03-01
期刊：
影响因子：
13.7
通讯作者：
Jacobs, DR
中科院分区：
文献类型：
--
作者：
Klein, R;Klein, BEK;Jacobs, DR
目的：描述4个人种/种族组中年龄相关性黄斑变性（AMD）的患病率（白色、黑人、西班牙裔和中国人），这些人参加了动脉粥样硬化多种族研究（梅萨）的第二次检查。设计：前瞻性队列研究。参与者：从美国6个社区选出的6176名45- 85岁的受试者。方法：使用450数码相机通过暗适应瞳孔拍摄眼底图像，并使用改良的威斯康星州视网膜相关黄斑病变分级系统对玻璃疣大小、类型、面积、视网膜色素增加、视网膜色素上皮脱色、新生血管病变和地图样萎缩进行分级。主要结果测量：视网膜相关黄斑变性。AMD的患病率分别为2.4%（黑人）、4.2%（西班牙裔）、4.6%（中国人）和5.4%（白色人）（各组间差异均P < 0.001）。任何AMD的最高患病率发生在75至84岁的人群中，从黑人的7.4%到白人和中国人的15.8%不等（P = 0.03）。晚期AMD的估计患病率为0.3%（黑人）、0.2%（西班牙裔）、0.6%（白色）和1.0%（中国人）。这些差异是轻微的显着性（年龄和性别调整，P = 0.08）。与白人相比，中国人渗出性AMD的发生率最高（年龄和性别调整的比值比为4.30; 95%置信区间为1.30-14.27）。年龄，性别，瞳孔大小，身体质量指数，吸烟，饮酒史，糖尿病，高血压状态的差异并没有解释的变异之间的4种族/ethnic groups.Conclusions：低患病率的AMD被发现在梅萨队列中的所有组。与白人相比，黑人中AMD的患病率较低。渗出型AMD在中国人中的较高患病率有待进一步研究。
Objective: To describe the prevalence of age-related macular degeneration (AMD) in 4 racial/ethnic groups (white, black, Hispanic, and Chinese) that participated in the second examination of the Multi-ethnic Study of Atherosclerosis (MESA).Design: Prospective cohort study.Participants: Six thousand one hundred seventy-six 45- to 85-year-old subjects selected from 6 United States communities.Methods: Fundus images were taken using a 450 digital camera through dark-adapted pupils and were graded for drusen size, type, area, increased retinal pigment, retinal pigment epithelial depigmentation, neovascular lesions, and geographic atrophy using the modified Wisconsin Age-Related Maculopathy Grading System.Main Outcome Measure: Age-related macular degeneration.Results: Prevalences of AMD were 2.4% (black), 4.2% (Hispanic), 4.6% (Chinese), to 5.4% (white) (P < 0.001 for any differences among groups). The highest prevalence of any AMD occurred in those 75 to 84 years old, varying from 7.4% in blacks to 15.8% in whites and Chinese (P = 0.03). Estimated prevalences of late AMD were 0.3% (black), 0.2% (Hispanic), 0.6% (white), and 1.0% (Chinese). These differences were marginally significant (age and gender adjusted, P = 0.08). The frequency of exudative AMD was highest in Chinese (age- and gender-adjusted odds ratio, 4.30; 95% confidence interval, 1.30-14.27) compared with whites. Differences in age, gender, pupil size, body mass index, smoking, alcohol drinking history, diabetes, and hypertension status did not explain the variability among the 4 racial/ethnic groups.Conclusions: Low prevalences of AMD were found in the MESA cohort in all groups. A lower prevalence of AMD was found in blacks compared with whites. The higher prevalence of exudative AMD in Chinese needs further study.