Avian oncovirus Mill Hill No. 2: pathogenicity in chickens.
Avian oncovirus Mill Hill No. 2: pathogenicity in chickens.
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禽肿瘤病毒 Mill Hill 2 号：对鸡的致病性。
DOI：
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发表时间：
1979
期刊：
影响因子：
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通讯作者：
P. Vogt
中科院分区：
文献类型：
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作者：
R. Alexander;C. Moscovici;P. Vogt
Mill Hill No. 2 (MH2) 是一种禽类肿瘤病毒，对其转化和致癌作用进行了研究。在组织培养中，它诱导鸡成纤维细胞和卵黄囊巨噬细胞的转化。当注射到鸡体内时，这种病毒的主要特征是除了肉瘤之外，还能引起肝癌和肾癌。 MH2相关病毒不会转化细胞培养物，但只能引起鸟类淋巴瘤。使用光学和电子显微镜对 MH2 病毒诱导的肿瘤进行详细的组织学研究。注射部位的软组织中产生了未分类的圆形细胞肉瘤；没有证据表明源自内皮细胞。在肾脏中，发现了与恶性间质混合的癌。肝癌是肝脏中发现的主要肿瘤。相关病毒产生的淋巴瘤分化差且高度恶性。该研究说明了该病毒的高度致癌潜力，并为以更具体的方式分析致癌事件提供了模型。
Mill Hill No. 2 (MH2), an avian tumor virus, was studied for its transforming and oncogenic effects. In tissue culture it induced transformation of chicken fibroblasts and yolk sac macrophages. When injected into the chicken, the main feature of this virus was its ability to cause liver and kidney carcinoma, in addition to sarcoma. MH2-associated viruses did not transform cell cultures but were able to cause only lymphoma in the birds. Light and electron microscopy were used in a detailed histologic study of the tumors induced by MH2 virus. An unclassified round cell sarcoma was produced in soft tissues at sites of injection; there was no evidence of origin from endothelium. In the kidney, carcinomas mixed with a malignant stroma were found. Hepatocarcinomas were the dominant tumors found in the liver. The lymphomas produced by the associated virus were poorly differentiated and highly malignant. The study illustrated the highly oncogenic potential of this virus and offered a model for the analysis of the carcinogenic events in a more specific way.