Whole-tumor histogram analysis of DWI and QSI for differentiating between meningioma and schwannoma: a pilot study
Whole-tumor histogram analysis of DWI and QSI for differentiating between meningioma and schwannoma: a pilot study
复制标题
DOI：
10.1007/s11604-019-00862-y
复制
发表时间：
2019-10-01
影响因子：
2.1
通讯作者：
Yamada, Kei
中科院分区：
文献类型：
--
作者：
Nagano, Hitomi;Sakai, Koji;Yamada, Kei
目的探讨是否全肿瘤直方图分析的扩散系数测量来自q空间成像（QSI）提高脑膜瘤和神经鞘瘤之间的鉴别。材料和方法15个轴外肿瘤（11个脑膜瘤和4个神经鞘瘤）的MR检查从2011年4月至2013年5月。三维感兴趣区域（ROI）涵盖整个肿瘤，包括囊性区域。在平均值、MDn和ADC（n）的五个阶数（n=5、25、50、75、95阶）、峰度和偏度下，对ROI的QSI和表观扩散系数（ADC）导出的平均位移（MD）进行直方图分析。结果直方图分析显示，脑膜瘤和神经鞘瘤的MD75、ADC（25）、ADC（50）、ADC（75）和ADC（n）的峰度均有显著性差异（P <0.05）。ADC和MD75峰度的ROC分析分别得到AUC为1.0和0.96。MD75的AUC与ADC的峰度的AUC之间无显著性差异（p=0.41）。结论QSI的MD和ADC直方图分析在脑膜瘤和神经鞘瘤的鉴别诊断中具有同等的价值。
Purpose To investigate whether whole-tumor histogram analyses of diffusivity measurements derived from q-space imaging (QSI) improves the differentiation between meningioma and schwannoma.Materials and methods Fifteen extra-axial tumors (11 meningiomas and 4 schwannomas) with MR examinations from April 2011 to May 2013 were included. Three-dimensional regions of interest (ROI) encompassed the whole tumor, including cystic areas. Histogram analyses of mean displacement (MD) derived from QSI and apparent diffusion coefficient (ADC) for the ROI were performed at mean, the five percentiles of MDn and ADC(n) (n=5, 25, 50, 75, 95th), kurtosis, and skewness. To determine the diagnostic ability of MDn and ADC(n), we also compared the area under the curve (AUC) on receiver operating characteristic (ROC) analysis.Results Histogram analyses revealed significant differences between meningioma and schwannoma in MD75, ADC(25), ADC(50), ADC(75), and kurtosis of ADC. The ROC analysis of kurtosis of ADC and MD75 resulted in an AUC of 1.0 and 0.96, respectively. There were no significant differences between the AUC of MD75 and that of kurtosis of ADC (p=0.41).Conclusion The histogram analyses of MD and ADC derived from QSI were both equally useful in differentiating between intracranial meningioma and schwannoma.