TANGENTIAL ORGANIZATION OF THALAMIC PROJECTIONS TO THE NEOCORTEX IN THE MOUSE
TANGENTIAL ORGANIZATION OF THALAMIC PROJECTIONS TO THE NEOCORTEX IN THE MOUSE
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DOI：
10.1002/cne.901940205
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发表时间：
1980-01-01
影响因子：
2.5
通讯作者：
FROST, DO
中科院分区：
文献类型：
--
作者：
CAVINESS, VS;FROST, DO
顺行变性技术被用来检查的切线组织的离丘脑轴突人口（I类弗罗斯特和空洞），其终端优先分布到中间层（位于第三层和/或第四层）的3个径向分离层的丘脑投影到新皮质。不太广泛的数据也提出了离丘脑轴突人口（II类弗罗斯特和Caviness），不终止优先在中间层的切线组织，但在其他方面的异质性相对于他们的径向图案的皮质内终止。I类轴突的投影分布到所有新皮质区域，可能除了区域13、25和35。I类投射到一个给定的皮质区（可能除了第二躯体感觉代表的皮质）起源于只有一个丘脑核。单个丘脑核的I类投射形成了构成核体积的一阶线到线（拓扑）变换的核的皮质表示。I类投影的集合形成相应丘脑区域的皮质表示，其构成丘脑体积的二阶线到线（非拓扑）变换。II类轴突投射到所有的新皮层区域。II类和I类投影的对比在于，多个丘脑核的II类投影在皮质的任何给定扇区的切向平面中重叠。虽然II类预测的intralaminar核和广泛突出的腹内侧核的拓扑组织，切线组织的II类预测产生的其他核是不完全理解。
The anterograde degeneration technique was used to examine the tangential organization of a thalamofugal axon population (class I of Frost and Caviness) whose terminations are preferentially distributed to the middle tier (located in layers III and/or IV) of 3 radially separated tiers of thalamic projections to the neocortex. Less extensive data are also presented on the tangential organization of thalamofugal axon populations (class II of Frost and Caviness) that do not terminate preferentially in the middle tier, but that are otherwise heterogeneous with respect to their radial pattern of intracortical termination. The projections of class I axons are distributed to all neocortical fields with the possible exception of fields 13, 25 and 35. The class I projections to a given cortical field (with the possible exception of the cortex of the 2nd somatosensory representation) originate in only 1 thalamic nucleus. The class I projections of an individual thalamic nucleus form a cortical representation of the nucleus that constitutes a first order line-to-line (topologic) transformation of the nuclear volume. The ensemble of class I projections forms a cortical representation of the corresponding thalamic regions that constitutes a second order line-to-line (non-topologic) transformation of the thalamic volume. Class II axons project to all neocortical fields. Class II and class I projections contrast in that the class II projections of multiple thalamic nuclei overlap in the tangential plane of any given sector of the cortex. While the class II projections of the intralaminar nuclei and the widely projecting ventromedial nucleus are topologically organized, the tangential organization of class II projections arising in other nuclei is incompletely understood.