Random nucleotide substitutions in primate nonfunctional gene for L-gulono-γ-lactone oxidase, the missing enzyme in L-ascorbic acid biosynthesis
Random nucleotide substitutions in primate nonfunctional gene for L-gulono-γ-lactone oxidase, the missing enzyme in L-ascorbic acid biosynthesis
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DOI：
10.1016/s0304-4165(99)00123-3
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发表时间：
1999-10-18
影响因子：
3
通讯作者：
Nishikimi, M
中科院分区：
文献类型：
--
作者：
Ohta, Y;Nishikimi, M
人类和其他灵长类动物没有L-古洛糖酸-γ-内酯氧化酶的功能基因，该氧化酶催化L-抗坏血酸生物合成的最后一步。将该基因外显子X的164个核苷酸序列在人类、黑猩猩、猩猩和猕猴中进行比较，发现核苷酸替换在整个序列中随机发生，并且有一个核苷酸缺失，这表明灵长类动物L-古洛糖酸-γ-内酯氧化酶基因是假基因的典型例子。(C)1999 Elsevier Science B. V.保留所有权利。
Humans and other primates have no functional gene for L-gulono-gamma-lactone oxidase that catalyzes the last step of L-ascorbic acid biosynthesis. The 164-nucleotide sequence of exon X of the gene was compared among human, chimpanzee, orangutan, and macaque, and it was found that nucleotide substitutions had occurred at random throughout the sequence with a single nucleotide deletion, indicating that the primate L-gulono-gamma-lactone oxidase genes are a typical example of pseudogene. (C) 1999 Elsevier Science B.V. All rights reserved.