Gastroesophageal reflux disease and sleep disorders: evidence for a causal link and therapeutic implications.
Gastroesophageal reflux disease and sleep disorders: evidence for a causal link and therapeutic implications.
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DOI：
10.5056/jnm.2010.16.1.22
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发表时间：
2010-01
影响因子：
3.4
通讯作者：
Talley NJ
中科院分区：
文献类型：
--
作者：
Jung HK;Choung RS;Talley NJ
胃食道反流病(GERD)和睡眠障碍都是常见的健康问题。睡眠障碍和GERD之间存在显著的关联，这可能是双向的。睡眠障碍可能导致胃肠道(GI)紊乱，而GI症状也可能引发或恶化睡眠紊乱。胃酸反流在睡眠中较少发生，然而，胃酸清除机制(包括吞咽、流口水和初级食道运动)在睡眠中受损，导致酸接触时间延长。夜间反流会导致睡眠障碍，睡眠障碍可能会通过延长酸接触时间和增强感官知觉而进一步加重GERD。这可能促进复杂的GERD的发生和生活质量的下降。然而，睡眠问题和GERD之间的相互作用是复杂的，关于这个问题的数据仍然相对有限。对睡眠相关GERD的进一步研究可能确定共同的病理生理学主题和新的治疗靶点。
Gastroesophageal reflux disease (GERD) and sleep disturbances are both common health problems. There is a significant association between disturbed sleep and GERD, and this may be bidirectional. Sleep disorders may induce gastrointestinal (GI) disturbances, while GI symptoms also may provoke or worsen sleep derangements. Reflux of gastric acid is a less frequent event during sleep, however, acid clearance mechanisms (including swallowing, salivation and primary esophageal motility) are impaired during sleep resulting in prolongation of acid contact time. Nighttime reflux can lead to sleep disturbance and sleep disturbance may further aggravate GERD by prolonged acid contact time and heightened sensory perception. This may facilitate the occurrence of complicated GERD and decreased quality of life. However, the interplay between sleep problems and GERD is complex, and there are still relatively limited data on this issue. Further investigation of sleep-related GERD may identify common pathophysiological themes and new therapeutic targets.