LEARNING OF SEQUENTIAL FINGER MOVEMENTS IN MAN - A COMBINED KINEMATIC AND POSITRON EMISSION TOMOGRAPHY (PET) STUDY
LEARNING OF SEQUENTIAL FINGER MOVEMENTS IN MAN - A COMBINED KINEMATIC AND POSITRON EMISSION TOMOGRAPHY (PET) STUDY
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DOI：
10.1111/j.1460-9568.1992.tb00862.x
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发表时间：
1992-02-01
影响因子：
3.4
通讯作者：
ROLAND, PE
中科院分区：
文献类型：
--
作者：
SEITZ, RJ;ROLAND, PE
通过对9名健康志愿者进行局部脑血流量(RCBF)测量和正电子发射断层扫描，绘制了参与学习手工技能的大脑结构图。这项任务是一个复杂的右手手指运动序列。受试者被分三个阶段进行检查：在手指动作序列的初始练习期间，在学习的高级阶段，以及在他们学习了手指动作序列之后。对右前臂和手部肌肉的录像带和肌电记录的定量评估表明，手指的运动明显加快，变得更加规则。左侧运动手区、左侧运动前皮质、左侧辅助运动区、左侧感觉手区、左侧辅助感觉区和右侧小脑前叶RCBF显著增加。在学习过程中，双侧顶上小叶、前顶叶和右侧额下角三角部的平均RCBF显著降低。在学习初期，这些结构的平均RCBF增加与躯体感觉反馈处理和指导手指运动的内部语言有关。当受试者学习了手指的移动顺序后，这些激活就消失了。相反，在学习过程中，左侧壳核和苍白球中段的平均RCBF显著升高。有人认为，在这个动作序列的学习阶段，基底节在最终运动程序的建立中起着至关重要的作用。
The cerebral structures participating in learning of a manual skill were mapped with regional cerebral blood flow (rCBF) measurements and positron emission tomography in nine healthy volunteers. The task was a complicated right-hand finger movement sequence. The subjects were examined at three stages: during initial practice of the finger movement sequence, in an advanced stage of learning, and after they had learnt the finger movement sequence. Quantitative evaluation of video tapes and electromyographic records of the right forearm and hand muscles demonstrated that the finger movements significantly accelerated and became more regular. Significant mean RCBF increases were induced in the left motor hand area, the left premotor cortex, the left supplementary motor area, the left sensory hand area, the left supplementary sensory area and the right anterior lobe of the cerebellum. During the learning process significant depressions of the mean RCBF occurred bilaterally in the superior parietal lobule, the anterior parietal cortex and the pars triangularis of the right inferior frontal cortex. The mean RCBF increases in these structures during the initial stage of learning were related to somatosensory feedback processing and internal language for the guidance of the finger movements. These activations disappeared when the subjects had learnt the finger movement sequence. Conversely, the mean RCBF significantly rose during the course of learning in the midsector of the putamen and globus pallidus on the left side. It is suggested that during the learning phase of this movement sequence, the basal ganglia were critically involved in the establishment of the final motor programme.