Synthesis of Chromeno[3,4-b]pyrrol-4(3H)-ones through the Domino Cyclization of 3-Aminocoumarins with Arylglyoxal Monohydrates
Synthesis of Chromeno[3,4-b]pyrrol-4(3H)-ones through the Domino Cyclization of 3-Aminocoumarins with Arylglyoxal Monohydrates
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通过 3-氨基香豆素与芳基乙二醛一水合物的多米诺环化合成色并[3,4-b]吡咯-4(3H)-酮
DOI：
10.1002/ejoc.201700054
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发表时间：
2017
影响因子：
2.8
通讯作者：
Zhong Weihui
中科院分区：
文献类型：
--
作者：
Yang Xiaofeng;Chen Zhiwei;Zhong Weihui
在对甲苯磺酸(p-TSA)的催化下，3-氨基香豆素与芳基乙醛一水合物发生多米诺骨牌环化反应，合成了两个色烯并[3，4-b]吡咯-4(~3H)-酮衍生物。使用简单的加工程序，以中等到极好的产率获得产品。甲苯和乙醇在具有不同取代方式的吡咯环香豆素衍生物的选择性形成中起着重要作用。
A facile and efficient domino cyclization between 3‐aminocoumarins and arylglyoxal monohydrates in the presence ofpara‐toluenesulfonic acid (p‐TSA) as a promoter was employed for the synthesis of two libraries of chromeno[3,4‐b]pyrrol‐4(3H)‐one derivatives. Simple workup procedures were used to obtain the products in moderate to excellent yields. The solvents toluene and ethanol served important roles in the selective formation of the pyrrolocoumarin derivatives characterized by their different substitution patterns.