GLOMERULAR DEPOSITION OF PROPERDIN IN HENOCH-SCHONLEIN SYNDROME AND IDIOPATHIC FOCAL NEPHRITIS
GLOMERULAR DEPOSITION OF PROPERDIN IN HENOCH-SCHONLEIN SYNDROME AND IDIOPATHIC FOCAL NEPHRITIS
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DOI：
10.1136/bmj.3.5875.326
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发表时间：
1973-01-01
影响因子：
105.7
通讯作者：
HOFFBRAND, BI
中科院分区：
文献类型：
--
作者：
EVANS, DJ;WILLIAMS, DG;HOFFBRAND, BI
4例特发性局灶性肾炎和3例Henoch-Schönlein综合征患者的肾组织活检显示，C3和properdin与IgA在肾小球系膜沉积，C1q未检出。这些观察结果表明，以肾小球系膜IgA和C3沉积为特征的肾小球损伤是通过特异蛋白系统介导的。
Biopsy of renal tissue from four patients with idiopathic focal nephritis and three patients with Henoch-Schönlein syndrome showed that C3 and properdin were deposited with IgA in the glomerular mesangium, C1q could not be detected. These observations suggest that glomerular injury in disorders characterized by mesangial deposits of IgA and C3 is mediated via the properdin system.