Enhanced sympathetic and ventilatory responses to central chemoreflex activation in heart failure
Enhanced sympathetic and ventilatory responses to central chemoreflex activation in heart failure
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DOI：
10.1161/01.cir.100.3.262
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发表时间：
1999-07-20
期刊：
影响因子：
37.8
通讯作者：
Somers, VK
中科院分区：
文献类型：
--
作者：
Narkiewicz, K;Pesek, CA;Somers, VK
Background-Sympathetic activation and respiratory abnormalities may each be implicated in the pathophysiology of congestive heart failure (CHF). Chemoreflexes are an important mechanism regulating both sympathetic drive and breathing. We therefore tested the hypothesis that chemoreflex function is altered in CHF.Methods and Results-We compared ventilatory, sympathetic, heart rate, and blood pressure responses to hypoxia, hypercapnia, and the cold presser test in 9 patients with CHF and 9 control subjects matched for age and body mass index. Baseline muscle sympathetic nerve activity (MSNA) was higher in the patients with CHF compared with control subjects (47+/-8 versus 23+/-3 bursts per minute, P
