Does Preoperative Radio(chemo)therapy Increase Anastomotic Leakage in Rectal Cancer Surgery? A Meta-Analysis of Randomized Controlled Trials.
Does Preoperative Radio(chemo)therapy Increase Anastomotic Leakage in Rectal Cancer Surgery? A Meta-Analysis of Randomized Controlled Trials.
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术前放（化疗）治疗会增加直肠癌手术中的吻合口瘘吗？
DOI：
10.1155/2014/910956
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发表时间：
2014
影响因子：
2
通讯作者：
Song X
中科院分区：
文献类型：
--
作者：
Qin C;Ren X;Xu K;Chen Z;He Y;Song X
Objective.术前放疗（化疗）治疗（pR（C）T）似乎会增加直肠癌切除术后并发症，但临床试验报告了相互矛盾的结果。本荟萃分析旨在评估pR（C）T对直肠癌切除术后吻合口瘘的影响。方法.检索了PubMed、Embase和科克伦图书馆，检索时间为1980年1月至2014年1月。随机对照试验包括所有报告直肠癌患者吻合口瘘的原始文献，其中一些患者接受了术前放疗或放化疗，而另一些则没有。分析的终点是吻合口漏。结果.荟萃分析纳入了7项随机对照试验（3375例患者）。1660例患者形成接受术前放疗或放化疗的组，1715例患者未接受术前放疗或放化疗。荟萃分析发现，pR（C）T不是吻合口瘘的独立风险因素（OR 1.02，95% CI 0.80-1.30; P = 0.88）。进行亚组分析，结果未改变。结论.目前的证据表明，pR（C）T不会增加患者直肠癌切除术后吻合口瘘的风险。
Objective. Preoperative radio(chemo)therapy (pR(C)T) appears to increase postoperative complications of rectal cancer resection, but clinical trials have reported conflicting results. The objective of this meta-analysis was performed to assess the effects of pR(C)T on anastomotic leak after rectal cancer resection. Methods. PubMed, Embase, and the Cochrane Library were searched from January 1980 to January 2014. Randomized controlled trials included all original articles reporting anastomotic leak in patients with rectal cancer, among whom some received preoperative radiotherapy or chemoradiotherapy while others did not. The analysed end-points were the anastomotic leak. Result. Seven randomized controlled trials with 3375 patients were included in the meta-analysis. 1660 forming the group undergoing preoperative radiotherapy or chemoradiotherapy versus 1715 patients undergoing without preoperative radiotherapy or chemoradiotherapy. The meta-analyses found that pR(C)T was not an independent risk factor for anastomotic leakage (OR 1.02, 95% CI 0.80–1.30; P = 0.88). Subgroups analysis was performed and the result was not altered. Conclusions. Current evidence demonstrates that pR(C)T did not increase the risk of postoperative anastomotic leak after rectal cancer resection in patients.
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影响因子：
6.2
作者：
Park, Jin-hong;Yoon, Sang Min;Kim, Jin Cheon
通讯作者：
Kim, Jin Cheon
影响因子：
9
作者：
ROUANET, P;FABRE, JM;PUJOL, H
通讯作者：
PUJOL, H
影响因子：
3.7
作者：
de Campos-Lobato, Luiz Felipe;Stocchi, Luca;Kalady, Matthew F.
通讯作者：
Kalady, Matthew F.
影响因子：
3.9
作者：
Huh, Jung Wook;Kim, Hyeong Rok;Kim, Young Jin
通讯作者：
Kim, Young Jin
影响因子：
2.6
作者：
Lee, Won-Suk;Yun, Seong Hyeon;Chun, Ho-Kyung
通讯作者：
Chun, Ho-Kyung