MicroRNAs in gastric cancer metastasis.
MicroRNAs in gastric cancer metastasis.
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DOI：
10.1615/critreveukaryotgeneexpr.2014007896
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发表时间：
2014
影响因子：
1.6
通讯作者：
Zhaoqi Shi;Qingxia Wei;J. She
中科院分区：
文献类型：
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作者：
Zhaoqi Shi;Qingxia Wei;J. She
胃癌是世界范围内常见的恶性肿瘤，具有较高的转移率。肿瘤转移的分子机制尚不完全清楚。microRNA（miRNAs）是一种非编码的小RNA分子，在转录后调节基因表达，参与肿瘤转移的多个过程。阐明它们在胃癌转移中的作用将有助于提高对胃癌的认识。在此，我们综述了miRNA参与胃癌转移的多个步骤，包括上皮-间充质转化、失巢凋亡、血管生成、侵袭和迁移。本文还讨论了miRNA作为胃癌预后生物标志物的临床应用。
Gastric cancer (GC) is common worldwide and has a high rate of metastasis. The underlying molecular mechanism of metastasis are not entirely clear. MicroRNAs (miRNAs) are small, non-coding RNA molecules that regulate gene expression post-transcriptionally and are reported to be involved in multiple steps of tumor metastasis. Clarifying their roles in GC metastasis will improve understanding of this disease. Here, we review the involvement of miRNAs in multiple steps of GC metastasis, including epithelial-mesenchymal transitions, anoikis, angiogenesis, invasion, and migration. The clinical application of miRNAs as prognostic biomarkers in GC is also discussed.