Complete genome sequence of Vibrio fischeri:: A symbiotic bacterium with pathogenic congeners
Complete genome sequence of Vibrio fischeri:: A symbiotic bacterium with pathogenic congeners
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DOI：
10.1073/pnas.0409900102
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发表时间：
2005-02-22
影响因子：
11.1
通讯作者：
Greenberg, EP
中科院分区：
文献类型：
--
作者：
Ruby, EG;Urbanowski, M;Greenberg, EP
费氏弧菌属于弧菌科，这是一个海洋γ-变形菌大家族，其中包括数十种已知与动物组织发生多种有益或致病相互作用的物种。引起人类疾病的少数致病性弧菌包括霍乱弧菌、副溶血弧菌和创伤弧菌，它们是唯一已报道其基因组序列的弧菌科成员。弧菌属的非致病性成员，包括许多有益的共生体，构成了弧菌科的大部分，但这些物种都没有经过类似的检查。在这里，我们报告了 V. fischeri ES114 的基因组序列，它与短尾乌贼 Euprymna scolopes 的发光器官形成互利共生。对该序列的分析揭示了与霍乱弧菌和其他病原体惊人的相似之处。
Vibrio fischeri belong to the Vibrionaceae, a large family of marine gamma-proteobacteria that includes several dozen species known to engage in a diversity of beneficial or pathogenic interactions with animal tissue. Among the small number of pathogenic Vibrio species that cause human diseases are Vibrio cholerae, Vibrio parahaemolyticus, and Vibrio vulnificus, the only members of the Vibrionaceae that have had their genome sequences reported. Nonpathogenic members of the genus Vibrio, including a number of beneficial symbionts, make up the majority of the Vibrionaceae, but none of these species has been similarly examined. Here we report the genome sequence of V. fischeri ES114, which enters into a mutualistic symbiosis in the light organ of the bobtail squid, Euprymna scolopes. Analysis of this sequence has revealed surprising parallels with V. cholerae and other pathogens.