Determination of volatile organic compounds including alcohols in refill fluids and cartridges of electronic cigarettes by headspace solid-phase micro extraction and gas chromatography-mass spectrometry
Determination of volatile organic compounds including alcohols in refill fluids and cartridges of electronic cigarettes by headspace solid-phase micro extraction and gas chromatography-mass spectrometry
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DOI：
10.1007/s00216-016-0049-0
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发表时间：
2017-02-01
影响因子：
4.3
通讯作者：
Shin, Ho-Sang
中科院分区：
文献类型：
--
作者：
Lim, Hyun-Hee;Shin, Ho-Sang
建立了顶空固相微萃取（HS-SPME）-气相色谱-质谱（GC-MS）联用检测电子烟（EC）填充液和烟弹中14种挥发性有机化合物（VOCs）的分析方法。总共在283种调味液体、21种尼古丁液体和12种一次性检测盒中识别和定量了14种VOC。VOCs的检测浓度范围如下：苯（0.008-2.28 mg L-1），甲苯（0.006-0.687 mg L-1），（0.01-1.21 mg L-1），间二甲苯（0.002-1.13 mg L-1），对二甲苯（0.007-2.8 mg L-1），邻二甲苯（0.004-2.27 mg L-1），苯乙烯（0.011-0.339 mg L-1），乙酸乙酯（0.3-669.9 mg L-1），乙醇（16- 38，742 mg L-1），甲醇（66-3375 mg L-1），吡啶（0.077-99.7 mg L-1）、乙酰基吡嗪（0.077-147 mg L-1）、2，3，5-三甲基吡嗪（0.008-96.8 mg L-1）和八甲基环四硅氧烷（0.1-57.2 mg L-1）。苯，甲苯，二甲苯，间二甲苯，对二甲苯和邻二甲苯共存的样品，这可能是源于使用石油烃作为提取溶剂的香料和尼古丁从天然植物。发现液体样品中苯、甲醇和乙醇的最大检出浓度高于其作为药品中残留溶剂的授权最大限度。
An analytical method for the detection of 14 volatile organic compounds (VOCs) was developed to investigate VOCs in refill fluids and cartridges of electronic cigarettes (EC) using headspace solid-phase micro extraction (HS-SPME) coupled with gas chromatography-mass spectrometry (GC-MS). In total, 14 VOCs were identified and quantified in 283 flavored liquids, 21 nicotine liquids, and 12 disposable cartridges. The detected concentration ranges of the VOCs are as follows: benzene (0.008-2.28 mg L-1), toluene (0.006-0.687 mg L-1), ethylbenzene (0.01-1.21 mg L-1), m-xylene (0.002-1.13 mg L-1), p-xylene (0.007-2.8 mg L-1), o-xylene (0.004-2.27 mg L-1), styrene (0.011-0.339 mg L-1), ethyl acetate (0.3-669.9 mg L-1), ethanol (16-38,742 mg L-1), methanol (66-3375 mg L-1), pyridine (0.077-99.7 mg L-1), acetylpyrazine (0.077-147 mg L-1), 2,3,5-trimethylpyrazine (0.008-96.8 mg L-1), and octamethylcyclotetrasiloxane (0.1-57.2 mg L-1). Benzene, toluene, ethylbenzene, m-xylene, p-xylene, and o-xylene coexisted in samples, which may have originated from the use of petrogenic hydrocarbons as an extraction solvent for flavor and nicotine from natural plants. The maximum detected concentrations of benzene, methanol, and ethanol in liquid samples were found in quantities higher than their authorized maximum limits as residual solvents in pharmaceutical products.