Mechanisms of abdominal aortic aneurysm formation.
Mechanisms of abdominal aortic aneurysm formation.
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DOI：
10.1007/s11883-002-0023-5
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发表时间：
2002-05-01
影响因子：
5.8
通讯作者：
Cassis, Lisa A
中科院分区：
文献类型：
--
作者：
Daugherty, Alan;Cassis, Lisa A
腹主动脉瘤（AAA）是肾下区域的永久性扩张，其中动脉组织以炎症和中膜变性为特征。AAA是一种常见的血管疾病，在老年人群中会导致显著的死亡率。尽管这种疾病的发病率很高，但对血管病理学机制的了解有限。因此，目前的治疗选择仅限于手术干预，并基于血管扩张时假定的破裂倾向。目前的研究集中在炎症过程及其在血管壁弹性蛋白和胶原纤维的蛋白水解降解中的作用。明确具体机制将有助于确定潜在药物干预的靶点，并显著改善AAA的药物治疗和预后。
Abdominal aortic aneurysms (AAA) are permanent dilations in the infra-renal area in which the arterial tissue is characterized by inflammation and medial degeneration. AAAs are a common vascular disorder and cause significant mortality in the aged population. Despite the high prevalence of this disease, there is limited knowledge on the mechanisms responsible for the vascular pathology. Therefore, current therapeutic options are restricted to surgical intervention and are predicated on the assumed propensity for rupture as the vessel enlarges. Current research focuses on inflammatory processes and their role in proteolytic degradation of the elastin and collagen fibers of the vessel wall. Definition of specific mechanisms would identify target sites for potential pharmacologic intervention and markedly improve the medical treatment and prognosis of AAA.