Long-term inhaled corticosteroids in preschool children at high risk for asthma
Long-term inhaled corticosteroids in preschool children at high risk for asthma
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DOI：
10.1056/nejmoa051378
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发表时间：
2006-05-11
影响因子：
158.5
通讯作者：
Martinez, FD
中科院分区：
文献类型：
--
作者：
Guilbert, TW;Morgan, WJ;Martinez, FD
背景：目前尚不清楚吸入皮质类固醇是否可以改变哮喘高危学龄前儿童随后的哮喘发展。方法：我们随机分配 285 名哮喘预测指数呈阳性的两岁或三岁参与者接受丙酸氟替卡松（剂量为 88 微克，每日两次）或安慰剂治疗，为期两年，随后一年不接受研究药物治疗。主要结局为观察年内无发作天数比例。结果：观察年内，两组间无发作天数比例、病情加重次数或肺功能均无显着差异。在治疗期间，与使用安慰剂相比，使用吸入性皮质类固醇与较高比例的无发作天数相关（P = 0.006）和较低的病情加重率（P
BACKGROUND:It is unknown whether inhaled corticosteroids can modify the subsequent development of asthma in preschool children at high risk for asthma.METHODS:We randomly assigned 285 participants two or three years of age with a positive asthma predictive index to treatment with fluticasone propionate (at a dose of 88 microg twice daily) or masked placebo for two years, followed by a one-year period without study medication. The primary outcome was the proportion of episode-free days during the observation year.RESULTS:During the observation year, no significant differences were seen between the two groups in the proportion of episode-free days, the number of exacerbations, or lung function. During the treatment period, as compared with placebo use, use of the inhaled corticosteroid was associated with a greater proportion of episode-free days (P=0.006) and a lower rate of exacerbations (P