Evaluation of serum transferrin receptor and sTfR ferritin indices in diagnosing and differentiating iron deficiency anemia from anemia of chronic disease
Evaluation of serum transferrin receptor and sTfR ferritin indices in diagnosing and differentiating iron deficiency anemia from anemia of chronic disease
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DOI：
10.1007/s12098-009-0302-z
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发表时间：
2010-02-01
影响因子：
4.3
通讯作者：
Malhan, Priya
中科院分区：
文献类型：
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作者：
Jain, Shilpa;Narayan, Shashi;Malhan, Priya
本研究旨在评价血清转铁蛋白受体(STfR)和铁蛋白指数在鉴别ACD和IDA以及诊断IDA和ACD共存方面的价值。所有患者和对照组均行全血象、外周血涂片、ACD标志物、铁谱(包括血清铁蛋白和血清转铁蛋白受体水平)检查。计算血清转铁蛋白受体和铁蛋白指数。缺铁性贫血组血清转铁蛋白受体水平显著高于非缺铁性贫血组(p<；0.001)。根据sTfR水平将ACD组进一步细分为两组(B1和Lt；3mUg/m l和B2a/千元Mu/m l)，提示B2组同时存在IDA。所有合并IDA的IDA和ACD患者的sTfR/log铁蛋白指数均为1.5，而所有单纯ACD患者和对照组的sTfR/log铁蛋白指数均为1.5。IDA组所有病例的LogsTfR/血清铁蛋白指数均为2.55，伴或不伴铁缺乏的ACD患者的logsTfR/血清铁蛋白比值均为2.55。sTfR水平和上述指标对鉴别单纯IDA、ACD和ACD并存的铁缺乏有很大的帮助，从而提供了一种非侵入性替代骨髓铁的方法。
The present study was conducted to assess the utility of serum transferrin receptor (sTfR) and sTfR ferritin indices to differentiate ACD from IDA and also to diagnose coexisting IDA and ACD.The study group comprised of 30 IDA patients, 30 cases of ACD and 30 age and sex matched controls. Complete hemogram with peripheral smear examination, markers of ACD, iron profile including serum ferritin and serum transferrin receptor levels were done in all patients and controls. Serum TfR and ferritin indices were calculated.sTfR levels were significantly higher in the IDA group compared to ACD group (p < 0.001). ACD group was further subdivided into two groups on the basis of sTfR levels (B1 < 3 mu g/ml and B2 a parts per thousand yen mu g/ml), suggesting coexisting IDA in group B2. sTfR/log ferritin index was > 1.5 in all cases of IDA and ACD with coexisting IDA while all pure ACD cases and control subjects had sTfR/log ferritin index < 1.5. All case in IDA group had log sTfR/serum ferritin index > 2.55 and all patients with ACD with or without associated iron deficiency had log sTfR/serum ferritin ratio < 2.55.The sTfR levels along with the above mentioned indices can be very useful in differentiating pure IDA, ACD and ACD with coexisting iron deficiency, thus providing a noninvasive alternative to bone marrow iron.