Control for Confounding in Case-Control Studies Using the Stratification Score, a Retrospective Balancing Score
Control for Confounding in Case-Control Studies Using the Stratification Score, a Retrospective Balancing Score
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DOI：
10.1093/aje/kwq406
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发表时间：
2011-04-01
影响因子：
5
通讯作者：
Satten, Glen A.
中科院分区：
文献类型：
--
作者：
Allen, Andrew S.;Satten, Glen A.
病例对照研究的分层评分是作为潜在混杂因素的函数建模的疾病概率。作者表明，分层评分是一种回顾性平衡评分，因此在病例对照研究中扮演的角色与倾向评分在前瞻性研究中扮演的角色相似。作者进一步说明，如果两组混杂协变量的分布相同，则如何使用分层评分的标准化来比较病例和对照参与者之间的暴露分布。作者使用了一项全基因组关联研究的数据来说明这些结果，该研究名为GAIN（遗传关联信息网络），研究非洲裔美国人的精神分裂症（2006-2008）。
The stratification score for a case-control study is the probability of disease modeled as a function of potential confounders. The authors show that the stratification score is a retrospective balancing score and thus plays a similar role in case-control studies as the propensity score plays in prospective studies. The authors further show how standardization using the stratification score can be used to compare the distributions of exposures that would be found among case and control participants if both groups had the same distribution of confounding covariables. The authors illustrate these results using data from a genome-wide association study, the GAIN (Genetic Association Information Network) study of schizophrenia among African Americans (2006-2008).