Prediction of the ablated area by the spread of microbubbles during radiofrequency ablation of hepatocellular carcinoma
Prediction of the ablated area by the spread of microbubbles during radiofrequency ablation of hepatocellular carcinoma
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DOI：
10.1111/j.1478-3231.2005.01145.x
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发表时间：
2005-10-01
影响因子：
6.7
通讯作者：
Shiratori, Y
中科院分区：
文献类型：
--
作者：
Nouso, K;Shiraga, K;Shiratori, Y
背景/目的：射频消融（RFA）是治疗肝细胞癌（HCC）的有效方法。为了防止消融邻近器官和血管，通过超声检查（US）观察射频消融过程中加热产生的微泡扩散，并用于预测消融面积;然而，几份报告记录了微泡扩散和消融面积之间存在差异。患者和方法：本文对24例肝癌患者行射频消融术（RFA），超声观察微泡的扩散情况，并与利声显超声造影（CE-US）在同一平面上的强化缺损进行比较。结果：消融过程中，后缘模糊，但消融后5 min可看到边界。消融后5 min强回声区的大小与CE-US观察到的缺损区大小相关（r（2）= 0.91，P < 0.0001）。高回声的形状与缺损区域对应良好，即使在微泡不规则扩散的情况下也是如此。结论：射频消融过程中微泡的观察可以预测消融区域，对防止邻近器官和血管的不良消融可能有一定的意义。
Background/Aim: Radiofrequency ablation (RFA) is effective for the treatment of hepatocellular carcinoma (HCC). To prevent the ablation of adjacent organs and vessels, the spread of microbubbles generated by heating during RFA was observed by ultrasonography (US) and used to predict the ablated area; however, several reports documented that discrepancies existed between the spread of microbubbles and the ablated area. Patients and Methods: The spread of microbubbles during RFA was observed by US in 24 patients with HCC and the areas were compared with the defect of enhancement in contrast enhanced (CE)-US, using Levovist in the same plane. Results: During the ablation, the posterior margin was obscure but the border could be visualized 5 min after the ablation. The size of the area of hyperechogenicity 5 min after ablation and that of the defect observed by CE-US was found to correlate (r(2) = 0.91, P < 0.0001). The shape of the hyperechogenicity corresponded well to the defect area, even in cases showing irregular spread of the microbubbles. Conclusion: The observation of microbubbles during RFA can predict the ablated area and might be useful to prevent the unfavorable ablation of adjacent organs and vessels.