Iron(III)-templated macrolactonization of trihydroxamate siderophores.
Iron(III)-templated macrolactonization of trihydroxamate siderophores.
复制标题
三异羟肟酸铁载体的铁(III)模板化大内酯化。
DOI：
10.1021/ol301869x
复制
发表时间：
2012
期刊：
影响因子：
5.2
通讯作者：
Miller,MarvinJ
中科院分区：
文献类型：
--
作者：
Wencewicz,TimothyA;Oliver,AllenG;Miller,MarvinJ
A method was developed to synthesize macrocyclic trihydroxamate siderophores using optimized Yamaguchi macrolactonization conditions. The natural ability of siderophores to bind iron(III) was exploited to template the reactions and allowed for rapid reaction rates, high product conversions, and the formation of large macrolactone rings up to 35 atoms. An X-ray structure of a 33-membered macrolactone siderophore–Fe(III) complex is presented.
