Left Ventricular Diastolic Function Is Associated With Symptom Status in Severe Aortic Valve Stenosis
Left Ventricular Diastolic Function Is Associated With Symptom Status in Severe Aortic Valve Stenosis
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DOI：
10.1161/circimaging.113.000636
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发表时间：
2014-01-01
影响因子：
7.5
通讯作者：
Moller, Jacob E.
中科院分区：
文献类型：
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作者：
Dahl, Jordi S.;Christensen, Nicolaj L.;Moller, Jacob E.
背景在主动脉瓣狭窄(AS)中，心力衰竭症状的发生并不总是与瓣膜狭窄的严重程度和左心功能相关。因此，我们检验了有症状的AS患者与无症状的患者相比，有症状的AS患者的舒张期、纵向收缩功能和左房扩张功能受损的假设。方法与结果在一项回顾性描述性研究中，我们比较了99例有症状和139例无症状的AS患者的临床特征和超声心动图参数，其中重度AS患者的左心室射血分数为50%。使用Logistic回归分析确定症状状态的独立预测因素。有症状的患者更年轻(7210岁比7612岁；P=0.002)，较少出现房颤(13%比24%；P=0.002)和慢性阻塞性肺疾病(2%比19%；P
Background In aortic valve stenosis (AS), the occurrence of heart failure symptoms does not always correlate with severity of valve stenosis and left ventricular (LV) function. Therefore, we tested the hypothesis that symptomatic patients with AS have impaired diastolic, longitudinal systolic function, and left atrial dilatation compared with asymptomatic patients.Methods and Results In a retrospective descriptive study, we compared clinical characteristics and echocardiographic parameters in 99 symptomatic and 139 asymptomatic patients with severe AS and LV ejection fraction 50%. Independent predictors of symptomatic state were identified using logistic regression analysis. Symptomatic patients were younger (7210 versus 7612 years of age; P=0.002), presented less often with atrial fibrillation (13% versus 24%; P=0.05) and chronic obstructive pulmonary disease (2% versus 19%; P