The evolution of nervous system centralization
The evolution of nervous system centralization
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DOI：
10.1098/rstb.2007.2242
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发表时间：
2008-04-27
影响因子：
6.3
通讯作者：
Tessmar-Raible, Kristin
中科院分区：
文献类型：
--
作者：
Arendt, Detlev;Denes, Alexandru S.;Tessmar-Raible, Kristin
目前尚不清楚双侧纲的中枢神经系统是何时以何种形式出现的，以及它是如何在不同的双侧纲中进一步进化的。为了找到答案，最近的一系列分子研究比较了进化缓慢的后口无脊椎动物和原口无脊椎动物的神经发育，例如肠肺纲半索纲囊舌动物和多毛环节动物Platynereis。这些研究集中在空间上不同的激活和，当访问时，功能的基因，建立神经外胚层的分子解剖和指定的神经元类型，从不同的分子坐标出现。复杂的相似性被检测到，这揭示了神经发育的方面，最有可能已经发生在一个类似的方式在最后的共同祖先的bilaterians，Urbilateria。通过这种方式，我们可以重建Urbilaterian神经系统分子结构的不同方面，并深入了解两侧对称祖先中的集中化程度。
It is yet unknown when and in what form the central nervous system in Bilateria first came into place and how it further evolved in the different bilaterian phyla. To find out, a series of recent molecular studies have compared neurodevelopment in slow-evolving deuterostome and protostome invertebrates, such as the enteropneust hemichordate Saccoglossus and the polychaete annelid Platynereis. These studies focus on the spatially different activation and, when accessible, function of genes that set up the molecular anatomy of the neuroectoderm and specify neuron types that emerge from distinct molecular coordinates. Complex similarities are detected, which reveal aspects of neurodevelopment that most likely occurred already in a similar manner in the last common ancestor of the bilaterians, Urbilateria. This way, different aspects of the molecular architecture of the urbilaterian nervous system are reconstructed and yield insight into the degree of centralization that was in place in the bilaterian ancestors.