Cerebral blood flow during hypoxic hypoxia with plasma-based hemoglobin at reduced hematocrit.
Cerebral blood flow during hypoxic hypoxia with plasma-based hemoglobin at reduced hematocrit.
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缺氧时的脑血流量，血细胞比容降低时血浆血红蛋白。
DOI：
10.1152/ajpheart.1998.274.6.h1933
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
Koehler,RC
中科院分区：
文献类型：
--
作者：
Ulatowski,JA;Bucci,E;Razynska,A;Traystman,RJ;Koehler,RC
我们确定了在缺氧缺氧期间，当红细胞压积和血红蛋白浓度独立地随着无细胞四聚体稳定血红蛋白输注而变化时，脑血流量（CBF）是否仍然与动脉O2含量（）相关。研究了三组戊巴比妥钠麻醉猫，动脉血氧饱和度分级降低至50%：1）对照组，红细胞压积为31 ± 1%（平均值±标准误;n= 7）;2）贫血组，红细胞压积为21 ± 1%，用白蛋白溶液进行等容换血（n= 8）;和3）输注分子内交联血红蛋白溶液以将红细胞压积降低至21 ± 1%的一组（n= 10）。血红蛋白输注后的总动脉血红蛋白浓度（g/dl）（8.8 ± 0.2）介于对照组（10.3 ± 0.3）和白蛋白组（7.2 ± 0.4）之间。在氧分压正常的情况下，输入白蛋白和血红蛋白后，前脑CBF增加，达到对照组在分级缺氧期间同等降低的水平。在动脉血氧饱和度和矢状窦血氧分压的广泛范围内 白蛋白组的CBF仍较高。当CBF对所有三组作图时，形成了一个单一的关系。缺氧期间脑氧转运、氧消耗和氧提取分数是恒定的，各组之间是相等的。我们的结论是，当红细胞压积降低时，无论携氧能力是否成比例降低，脑血流量仍然与低氧血症有关。因此，O2运输到大脑是很好地调节在一个恒定的水平，独立于血细胞比容，血红蛋白浓度和O2饱和度的变化。
We determined whether cerebral blood flow (CBF) remained related to arterial O2content () during hypoxic hypoxia when hematocrit and hemoglobin concentration were independently varied with cell-free, tetramerically stabilized hemoglobin transfusion. Three groups of pentobarbital sodium-anesthetized cats were studied with graded reductions in arterial O2saturation to 50%:1) a control group with a hematocrit of 31 ± 1% (mean ± SE;n= 7);2) an anemia group with a hematocrit of 21 ± 1% that underwent an isovolumic exchange transfusion with an albumin solution (n= 8); and3) a group transfused with an intramolecularly cross-linked hemoglobin solution to decrease hematocrit to 21 ± 1% (n= 10). Total arterial hemoglobin concentration (g/dl) after hemoglobin transfusion (8.8 ± 0.2) was intermediate between that of the control (10.3 ± 0.3) and albumin (7.2 ± 0.4) groups. Forebrain CBF increased after albumin and hemoglobin transfusion at normoxic O2tensions to levels attained at equivalent reductions inin the control group during graded hypoxia. Over a wide range of arterial O2saturation and sagittal sinus P O 2 , CBF remained greater in the albumin group. When CBF was plotted againstfor all three groups, a single relationship was formed. Cerebral O2transport, O2consumption, and fractional O2extraction were constant during hypoxia and equivalent among groups. We conclude that CBF remains related toduring hypoxemia when hematocrit is reduced with and without proportional reductions in O2-carrying capacity. Thus O2transport to the brain is well regulated at a constant level independently of alterations in hematocrit, hemoglobin concentration, and O2saturation.
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DOI：
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