Association of Systemic Lupus Erythematosus Disease Activity With Choroidal Thickness.
Association of Systemic Lupus Erythematosus Disease Activity With Choroidal Thickness.
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系统性红斑狼疮疾病活动与脉络膜厚度的关联。
DOI：
10.1097/rhu.0000000000002036
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发表时间：
2024
期刊：
影响因子：
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通讯作者：
Li,Tingting
中科院分区：
文献类型：
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作者：
Lee,Iris;Gomez,AndreaRamirez;Kim,AlfredHJ;Coble,DeanW;Marshall,Brigid;Shah,Aaditya;Eisen,Seth;Apte,RajendraS;Li,Tingting
目的 确定系统性红斑狼疮 (SLE) 患者疾病活动性与脉络膜厚度之间的关联。方法我们对 2019 年 6 月至 2021 年 11 月在华盛顿大学医学院招募的 24 名 SLE 患者和 13 名健康对照进行了队列研究。使用 SLE 疾病活动指数-2000 反应指数-50 (S2K RI-50) 评估 SLE 疾病活动性。将患者分为四组：高疾病活动性/无狼疮性肾炎（HDA/无 LN；S2K RI-50> 4）、HDA/活动性 LN（HDA/活动性 LN；S2K RI-50> 4）、低疾病活动性/无活动性 LN（LDA/无活动性 LN；S2K RI-50≤ 4）和 LDA/无 LN（LDA/无 LN；S2K） RI-50≤4)。 LDA/无 LN 患者与健康对照和其他 SLE 组患者的年龄、性别和种族相匹配。在疾病评估一周内拍摄的光学相干断层扫描图像上，在不知情的情况下，在中央凹水平切片上测量右眼脉络膜厚度。结果与匹配的 LDA 患者相比，HDA 患者的脉络膜增厚。在控制多重性后，脉络膜变薄在中央凹鼻部 1000 μm 处仍然具有统计学显着性（308±68 vs 228±64 μm，p = 0.001）。 LDA/无 LN 和 LDA/非活动性 LN 或健康对照之间的脉络膜厚度没有差异。结论 SLE 患者的 HDA 与脉络膜厚度增加相关，而共病非活动性 LN 不影响脉络膜厚度。需要在更大的纵向队列中进行更多研究，以研究脉络膜厚度是否可以用作 SLE 疾病活动性的非侵入性辅助指标。
ObjectiveTo determine the association between disease activity and choroidal thickness in patients with systemic lupus erythematosus (SLE).MethodsWe conducted a cohort study of 24 SLE patients and 13 healthy controls recruited at Washington University School of Medicine between June 2019 and November 2021. SLE disease activity was assessed using the SLE Disease Activity Index-2000 Responder Index-50 (S2K RI-50). Patients were divided into four groups: high disease activity/no lupus nephritis (HDA/no LN; S2K RI-50> 4), HDA/active LN (HDA/active LN; S2K RI-50> 4), low disease activity/inactive LN (LDA/inactive LN; S2K RI-50≤ 4), and LDA/no LN (LDA/no LN; S2K RI-50≤ 4). LDA/no LN patients were age-, sex-, and race-matched to healthy controls and patients in other SLE groups. Choroidal thickness of the right eye was measured blinded to disease activity on a horizontal section through the fovea on optical coherence tomography images taken within a week of disease assessment.ResultsPatients with HDA had choroidal thickening compared with matched patients with LDA. After controlling for multiplicity, choroidal thinning remained statistically significant at 1000 μm nasal to the fovea (308±68 vs 228±64 μm, p= 0.001). Choroidal thickness was not different between LDA/no LN and LDA/inactive LN or healthy controls.ConclusionHDA in patient with SLE is associated with increased choroidal thickness whereas comorbid inactive LN did not affect choroidal thickness. Additional studies in a larger longitudinal cohort are needed to study whether choroidal thickness may be used as a noninvasive, adjunctive measure for disease activity in SLE.