Kindlin-2 controls sensitivity of prostate cancer cells to cisplatin-induced cell death
Kindlin-2 controls sensitivity of prostate cancer cells to cisplatin-induced cell death
复制标题
Kindlin-2 控制前列腺癌细胞对顺铂诱导的细胞死亡的敏感性。
DOI：
10.1016/j.canlet.2010.08.003
复制
发表时间：
2010-12-18
期刊：
影响因子：
9.7
通讯作者：
Zhang, Hongquan
中科院分区：
文献类型：
--
作者：
Gong, Xiaowei;An, Zhengwen;Zhang, Hongquan
Resistance to anticancer drugs is often observed in prostate cancer therapy Kindlin 2 was recently found overexpressed during cancer progression In this study we examined the functional role of Kindlin-2 in cisplatin induced prostate cancer cell death Kindlin-2 was highly expressed in the androgen-insensitive (PC 3 and DU-145) but not in the androgen-sensitive cell lines (e g LNCaP) Overexpression of Kindlin-2 in LNCaP protected the cells from cisplatin-induced death while Kindlin-2 knock-down in PC-3 cells enhanced cis-platin sensitivity Mechanistically Kindlin-2 regulation of the anti apoptotic Bcl-xL may explain the increased cell death in the absence of Kindlin-2 Taken together Kindlin-2 appears to play a functional role in prostate cancer cell sensitivity to cisplatin Targeting Kindlin-2 may therefore improve drug efficacy and reduce drug doses and would likely be beneficial for the treatment of prostate cancer (C) 2010 Elsevier Ireland Ltd All rights reserved
