Recent advances in circadian rhythms in cardiovascular system.
Recent advances in circadian rhythms in cardiovascular system.
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DOI：
10.3389/fphar.2015.00071
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发表时间：
2015
影响因子：
5.6
通讯作者：
Yang G
中科院分区：
文献类型：
--
作者：
Chen L;Yang G
越来越多的证据表明，内在生物钟与心血管功能密切相关。血压和心率的昼夜变化是众所周知的昼夜节律。内皮功能、血小板聚集和血栓形成也表现出昼夜变化。许多心血管疾病（CVD）或事件（如心肌梗死、中风、心律失常和心源性猝死）的发作也表现出时间趋势。此外，来自动物模型和流行病学研究的有力证据表明，昼夜节律的破坏是许多CVD的重要风险因素，并且CVD的干预可能具有时间依赖性效应。本文综述了近年来关于昼夜节律与心血管生理和疾病（包括血压调节和心肌梗死）之间关系的研究进展。
Growing evidence shows that intrinsic circadian clocks are tightly related to cardiovascular functions. The diurnal changes in blood pressure and heart rate are well known circadian rhythms. Endothelial function, platelet aggregation and thrombus formation exhibit circadian changes as well. The onset of many cardiovascular diseases (CVDs) or events, such as myocardial infarction, stroke, arrhythmia, and sudden cardiac death, also exhibits temporal trends. Furthermore, there is strong evidence from animal models and epidemiological studies showing that disruption of circadian rhythms is a significant risk factor for many CVDs, and the intervention of CVDs may have a time dependent effect. In this mini review, we summarized recent advances in our understanding of the relationship between circadian rhythm and cardiovascular physiology and diseases including blood pressure regulation and myocardial infarction.
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影响因子：
82.9
作者：
通讯作者：
--
影响因子：
20.1
作者：
Frangogiannis NG
通讯作者：
Frangogiannis NG
DOI：
10.1152/ajpheart.00238.2012
发表时间：
2012-08-01
影响因子：
4.8
作者：
Lefta, Mellani;Campbell, Kenneth S.;Esser, Karyn A.
通讯作者：
Esser, Karyn A.
影响因子：
37.8
作者：
Anea CB;Zhang M;Stepp DW;Simkins GB;Reed G;Fulton DJ;Rudic RD
通讯作者：
Rudic RD
影响因子：
37.8
作者：
KURNIK, PB
通讯作者：
KURNIK, PB