Insect sex-pheromone signals mediated by specific combinations of olfactory receptors
Insect sex-pheromone signals mediated by specific combinations of olfactory receptors
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DOI：
10.1126/science.1106267
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发表时间：
2005-03-11
期刊：
影响因子：
56.9
通讯作者：
Touhara, K
中科院分区：
文献类型：
--
作者：
Nakagawa, T;Sakurai, T;Touhara, K
我们描述了两个配偶特异性嗅觉受体（OR）的蚕蛾，家蚕，这是相互排斥地表达在一对相邻的信息素敏感的神经元的配偶触角：一个是专门调谐到bombykol，性信息素，和其他bombykal，其氧化形式。这两种信息素OR与来自高度保守的昆虫OR亚家族的OR共表达。这种共表达促进信息素受体的功能表达，并赋予配体刺激的非选择性阳离子通道活性。在一般OR中也观察到相同的效应。气味和信息素信号通路都是通过昆虫中的共同机制介导的。
We describe two mate-specific olfactory receptors (ORs) in the silk moth, Bombyx mori, that are mutually exclusively expressed in a pair of adjacent pheromone-sensitive neurons of mate antennae: One is specifically tuned to bombykol, the sex pheromone, and the other to bombykal, its oxidized form. Both pheromone ORs are coexpressed with an OR from the highly conserved insect OR subfamily. This coexpression promotes the functional expression of pheromone receptors and confers ligand-stimulated nonselective cation channel activity. The same effects were also observed for general ORs. Both odorant and pheromone signaling pathways are mediated by means of a common mechanism in insects.