Building neural representations of habits
Building neural representations of habits
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DOI：
10.1126/science.286.5445.1745
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发表时间：
1999-11-26
期刊：
影响因子：
56.9
通讯作者：
Graybiel, AM
中科院分区：
文献类型：
--
作者：
Jog, MS;Kubota, Y;Graybiel, AM
习惯和技能的记忆（“内隐或程序记忆”）和事实的记忆（“外显或情景记忆”）是在不同的大脑系统中建立的，并且容易受到人类不同神经退行性疾病的影响。因此，可以研究基于纹状体的习惯形成机制，当大鼠学习T-迷宫程序任务时，用多个四极进行来自纹状体神经元集合的慢性记录。在行为习得过程中，感觉运动纹状体中神经元活动模式发生了大而广泛的变化，最终在任务相关活动中达到高潮，强调自动化过程的开始和结束。新的整体模式在随后的几周内保持稳定的相同任务的性能。这些结果表明，编码的行动在感觉运动纹状体进行动态重组的习惯学习的进行。
Memories for habits and skills ("implicit or procedural memory") and memories for facts ("explicit or episodic memory") are built up in different brain systems and are vulnerable to different neurodegenerative disorders in humans. So that the striatum-based mechanisms underlying habit formation could be studied, chronic recordings from ensembles of striatal neurons were made with multiple tetrodes as rats learned a T-maze procedural task. Large and widely distributed changes in the neuronal activity patterns occurred in the sensorimotor striatum during behavioral acquisition, culminating in task-related activity emphasizing the beginning and end of the automatized procedure. The new ensemble patterns remained stable during weeks of subsequent performance of the same task. These results suggest that the encoding of action in the sensorimotor striatum undergoes dynamic reorganization as habit learning proceeds.